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BG45

NMR下載 COA and HPLC MSDS下載
names：
BG45
CAS號：
926259-99-6
MDL Number：
MF(分子式)： C11H10N4O MW(分子量)： 214.22
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

BG45(cas:926259-99-6) is a potent and selective HDAC3 inhibitor inhibitor with selectivity for HDAC3 (IC50 = 289 nM) over HDAC1, 2. BG45 did not inihibit HDAC6. BG45 signigicantly inhibited tumor growth in a mouse model of multiple myeloma either alone and synergistically in combination with bortezomib. HDAC3 represents a promising therapeutic target, and validate a prototype novel HDAC3 inhibitor BG45 in MM.

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM001394B-10mg	10mg	99.71%	￥ 830.00	￥ 830.00		Instock1-2days	- +	￥ 0.00
YZM001394B-5mg	5mg	99.71%	￥ 585.00	￥ 585.00		Instock1-2days	- +	￥ 0.00

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中文別名	BG45(cas:926259-99-6)；HDAC3 inhibitor；HDAC3抑制劑
英文別名	BG45,926259-99-6
CAS號	926259-99-6
Inchi	InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
InchiKey	LMWPVSNHKACEKW-UHFFFAOYSA-N
分子式 Formula	C11H10N4O
分子量 Molecular Weight	214.22
溶解度Solubility	DMSO (Slightly), Methanol (Slightly)
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

BG45(CAS:926259-99-6)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

產(chǎn)品說明	BG45 (cas:926259-99is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).
Introduction	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

1. HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications. Harada T;Ohguchi H;Grondin Y;Kikuchi S;Sagawa M;Tai YT;Mazitschek R;Hideshima T;Anderson KC Leukemia. 2017 Dec;31(12)

2. .Histone deacetylase inhibitor BG45-mediated HO-1 expression induces apoptosis of multiple myeloma cells by the JAK2/STAT3 pathway. doi: 10.1097/CAD.0000000000000568.

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