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MC-Val-Cit-PAB-Auristatin E

NMR下載 COA and HPLC MSDS下載
names：
MC-Val-Cit-PAB-Auristatin E
CAS號(hào)：
2055896-77-8
MDL Number：
MF(分子式)： C68H108N11O13 MW(分子量)： 1287.65
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

MC-Val-Cit-PAB-Auristatin E(2055896-77-8) 是抗體-藥物偶聯(lián)物的一部分，由細(xì)胞毒性微管蛋白修飾劑 Auristatin E 和 ADC linker MC-Val-Cit-PAB 連接而成

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM001099-250mg	250mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM001099-100mg	100mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00

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中文別名	MC-Val-Cit-PAB-Auristatin E(2055896-77-8);MC Val Cit PAB Auristatin E
英文別名	MC-Val-Cit-PAB-Auristatin E,2055896-77-8
CAS號(hào)	2055896-77-8
Inchi	No data available
InchiKey	No data available
分子式 Formula	C68H108N11O13
分子量 Molecular Weight	1287.65
溶解度Solubility
性狀	Solid
儲(chǔ)藏條件 Storage conditions	短期1-2周儲(chǔ)存在-4℃條件下就行，長(zhǎng)期儲(chǔ)存（1-2年）需在-20℃條件下存儲(chǔ)

MC-Val-Cit-PAB-Auristatin E(2055896-77-8)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

MC-Val-Cit-PAB-Auristatin E(2055896-77-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:MC-Val-Cit-PAB-Auristatin E(2055896-77-8),MC-Val-Cit-PAB-Auristatin E試劑,MC-Val-Cit-PAB-Auristatin E的作用,MC-Val-Cit-PAB-Auristatin E的外觀,MC-Val-Cit-PAB-Auristatin E的溶解度,MC-Val-Cit-PAB-Auristatin E的廠家,MC-Val-Cit-PAB-Auristatin E的價(jià)格,MC-Val-Cit-PAB-Auristatin E的MSDS

產(chǎn)品說(shuō)明	MC-Val-Cit-PAB-Auristatin E(2055896-77-8)是ADC的藥物連接物偶聯(lián)物，具有有效的抗腫瘤活性。
Introduction	MC-Val-Cit-PAB-Auristatin E (2055896-77-8) is a drug linker conjugate of ADC with effective anti-tumor activity.
Application1	MC-Val-Cit-PAB-Auristatin E is a drug-linker conjugate for ADC with potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker MC-Val-Cit-PAB.
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)

Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates
Staben LR, et al.
The reversible attachment of a small-molecule drug to a carrier for targeted delivery can improve pharmacokinetics and the therapeutic index. Previous studies have reported the delivery of molecules that contain primary and secondary amines via an amide or carbamate bond; however, the ability to employ tertiary-amine-containing bioactive molecules has been elusive. Here we describe a bioreversible linkage based on a quaternary ammonium that can be used to connect a broad array of tertiary and heteroaryl amines to a carrier protein. Using a concise, protecting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that contain a range of reactive functional groups. We also show the utility of this connection with both protease-cleavable and reductively cleavable antibody-drug conjugates that were effective and stable in vitro and in vivo. Studies with a tertiary-amine-containing antibiotic show that the resulting antibody-antibiotic conjugate provided appropriate stability and release characteristics and led to an unexpected improvement in activity over the conjugates previously connected via a carbamate.

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MSDS

SDS 1.0 中文

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SDS 1.0 英文

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