購(gòu)物車(chē) 
-
Seco-Duocarmycin TM
- names：
Seco-Duocarmycin TM
- CAS號(hào)：
236102-87-7
MDL Number： - MF(分子式)： C25H24N2O6 MW(分子量)： 448.47
- EINECS: Reaxys Number:
- Pubchem ID:10003785 Brand:BIOFOUNT
Seco-Duocarmycin TM(236102-87-7)是杜卡霉素家族的一種 DNA 烷化劑，可抑制 DNA 合成。Seco-Duocarmycin TM 是一種細(xì)胞毒性劑，用作抗體偶聯(lián)藥物中的細(xì)胞毒性成分。
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM000941-100mg | 100mg | >95% | ￥ 139654.00 | ￥ 139654.00 | Backorder | ￥ 0.00 | ||
| YZM000941-25mg | 25mg | >95% | ￥ 40346.00 | ￥ 40346.00 | Backorder | ￥ 0.00 |
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| 中文別名 | Seco-Duocarmycin TM(236102-87-7) |
| 英文別名 | Seco-Duocarmycin TM,236102-87-7 |
| CAS號(hào) | 236102-87-7 |
| Inchi | InChI=1S/C25H24N2O6/c1-31-20-9-13-8-17(26-22(13)24(33-3)23(20)32-2)25(30)27-11-14(12-28)21-16-7-5-4-6-15(16)19(29)10-18(21)27/h4-10,14,26,28-29H,11-12H2,1-3H3/t14-/m0/s1 |
| InchiKey | ITTCPQPHJURTKF-AWEZNQCLSA-N |
| 分子式 Formula | C25H24N2O6 |
| 分子量 Molecular Weight | 448.47 |
| 溶解度Solubility | |
| 性狀 | Solid |
| 儲(chǔ)藏條件 Storage conditions | storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years) |
Seco-Duocarmycin TM(236102-87-7)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類(lèi)存儲(chǔ)，并交于專(zhuān)業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染
Seco-Duocarmycin TM(236102-87-7) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:Seco-Duocarmycin TM(236102-87-7),Seco-Duocarmycin TM試劑,Seco-Duocarmycin TM抑制劑,Seco-Duocarmycin TM的作用,Seco-Duocarmycin TM的純度,Seco-Duocarmycin TM的合成,Seco-Duocarmycin TM的生產(chǎn),Seco-Duocarmycin TM的廠家
| 產(chǎn)品說(shuō)明 | Seco-Duocarmycin TM(236102-87-7)是杜卡霉素家族的一種 DNA 烷化劑，可抑制 DNA 合成。 |
| Introduction | Seco-Duocarmycin TM (236102-87-7) is a DNA alkylating agent of the Dukamycin family, which can inhibit DNA synthesis. |
| Application1 | |
| Application2 | |
| Application3 |
| 警示圖 | |
| 危險(xiǎn)性 | warning |
| 危險(xiǎn)性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害 |
| 安全防護(hù) | P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理 |
| 備注 | 實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù) |
Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA
Abstract:Both 5-hydroxy- and 5-amino-seco-CBI-TMI minor groove alkylators are very potent cytotoxins. The patterns of alkylation of the two enantiomers of both compounds were compared on a section of the gpt gene. All of the compounds alkylated only at adenines, with the amino compounds being slightly more selective. Consensus alkylation sequences for both S (natural) enantiomers were identical, but for the R (unnatural) enantiomers these varied slightly. The consensus sequences suggest that the S enantiomers bind lying in the 3'-->5' direction from the alkylated adenine, but there was no clear indication of which direction the R enantiomers lie on the DNA. Both S enantiomers were 10- to 100-fold more efficient alkylators than the R enantiomers, and the amino compounds were somewhat more efficient than the corresponding phenols. The S enantiomers were more cytotoxic then the R in both the phenol and amino series. The large amounts of end-labelled DNA required for this work was obtained by first end-labelling appropriate primer oligonucleotides, then amplifying by PCR. Compared with other methods in use, this is a simple and flexible one-step procedure for the preparation of labelled DNA of any sequence. An improvement in the synthesis of 5-hydroxy-seco-CBI-TMI is reported.
Abstract:Both 5-hydroxy- and 5-amino-seco-CBI-TMI minor groove alkylators are very potent cytotoxins. The patterns of alkylation of the two enantiomers of both compounds were compared on a section of the gpt gene. All of the compounds alkylated only at adenines, with the amino compounds being slightly more selective. Consensus alkylation sequences for both S (natural) enantiomers were identical, but for the R (unnatural) enantiomers these varied slightly. The consensus sequences suggest that the S enantiomers bind lying in the 3'-->5' direction from the alkylated adenine, but there was no clear indication of which direction the R enantiomers lie on the DNA. Both S enantiomers were 10- to 100-fold more efficient alkylators than the R enantiomers, and the amino compounds were somewhat more efficient than the corresponding phenols. The S enantiomers were more cytotoxic then the R in both the phenol and amino series. The large amounts of end-labelled DNA required for this work was obtained by first end-labelling appropriate primer oligonucleotides, then amplifying by PCR. Compared with other methods in use, this is a simple and flexible one-step procedure for the preparation of labelled DNA of any sequence. An improvement in the synthesis of 5-hydroxy-seco-CBI-TMI is reported.
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