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RSV604 R enantiomer

NMR下載 COA and HPLC MSDS下載
names：
RSV604 R enantiomer
CAS號(hào)：
932108-20-8
MDL Number： MFCD30536208
MF(分子式)： C22H17FN4O2 MW(分子量)： 388.39
EINECS:No data available Reaxys Number:No data available
Pubchem ID:5279171 Brand:BIOFOUNT

RSV604 R enantiomer(932108-20-8) 是 RSV604 的 R 型對(duì)映體。RSV604 抑制呼吸道合胞病毒 (RSV) 復(fù)制。而 RSV604 R enantiomer 微弱作用于 RSV。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000875-5mg	5mg	>95%	￥ 7080.00	￥ 7080.00		3-5周	- +	￥ 0.00
YZM000875-2mg	2mg	>95%	￥ 3412.00	￥ 3412.00		3-5周	- +	￥ 0.00

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中文別名	RSV604 R enantiomer(932108-20-8);RSV604 racemate;RSV604 (racemate)
英文別名	RSV604 R enantiomer(932108-20-8);RSV604 racemate;RSV604 (racemate)
CAS號(hào)	932108-20-8
Inchi	InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m0/s1
InchiKey	MTPVBMVUENFFLL-FQEVSTJZSA-N
分子式 Formula	C22H17FN4O2
分子量 Molecular Weight	388.39
溶解度Solubility
性狀	固體粉末,Power
儲(chǔ)藏條件 Storage conditions	在-20°C條件下保存3年,在4°C條件下保存2年

RSV604 R enantiomer(932108-20-8)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

RSV604 R enantiomer(932108-20-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說(shuō)明	RSV604 R enantiomer(932108-20-8) 是 RSV604 的 R 型對(duì)映體。RSV604是呼吸道合胞病毒（RSV）復(fù)制的抑制劑。
Introduction	RSV604 R enantiomer (932108-20-8) is the R enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.

New strategies for control of respiratory syncytial virus infection

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.
Abstract:Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as representing a serious threat to patient groups with poorly functioning or immature immune systems. Racemic 1,4-benzodiazepines show potent anti-RSV activity in vitro. Anti-RSV evaluation of 3-position R- and S-benzodiazepine enantiomers and subsequent optimization of this series resulted in selection of a clinical candidate. Antiviral activity was found to reside mainly in the S-enantiomer, and the R-enantiomers were consistently less active against RSV. Analogues of 1,4-(S)-benzodiazepine were synthesized as part of the lead optimization program at Arrow and tested in the XTT assay. From this exercise, (S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)-urea, 17b (RSV-604) was identified as a clinical candidate, exhibiting potent anti-RSV activity in the XTT assay, which was confirmed in secondary assays. Compound 17b also possessed a good pharmacokinetic profile and has now progressed into the clinic.

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