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BPH-715

NMR下載 COA and HPLC MSDS下載
names：
BPH-715
CAS號(hào)：
1059677-23-4
MDL Number： No data available
MF(分子式)： C17H31NO7P2 MW(分子量)： 423.38
EINECS:No data available Reaxys Number:No data available
Pubchem ID:25014899 Brand:BIOFOUNT

BPH-715(1059677-23-4)是新一代的親脂性雙膦酸酯。 BPH-715在細(xì)胞培養(yǎng)中有效，并有效抑制腫瘤細(xì)胞的生長(zhǎng)和侵襲性。 BPH-715被用作阻斷蛋白質(zhì)異戊二烯化的抗癌劑，BPH-715也具有針對(duì)瘧原蟲(chóng)肝階段的有效活性。 BPH-715具有抗瘧原蟲(chóng)香葉基香葉基二磷酸合酶（GGPPS）的活性，以及對(duì)人法呢基和香葉基香葉基二磷酸香葉酯的低nM活性。BPH-715具有抗多種生物的活性，包括血液階段的瘧原蟲(chóng)。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000858-250mg	250mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00
YZM000858-100mg	100mg	>95%	￥ 0.00	￥ 0.00		Backorder	- +	￥ 0.00

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中文別名	BPH-715(1059677-23-4);BPH715;BPH 715
英文別名	BPH-715,1059677-23-4
CAS號(hào)	1059677-23-4
Inchi	InChI=1S/C17H31NO7P2/c1-2-3-4-5-6-7-8-9-13-25-16-11-10-12-18(14-16)15-17(26(19,20)21)27(22,23)24/h10-12,14,17H,2-9,13,15H2,1H3,(H3-,19,20,21,22,23,24)
InchiKey	QYJHUOZDBUEKQC-UHFFFAOYSA-N
分子式 Formula	C17H31NO7P2
分子量 Molecular Weight	423.38
溶解度Solubility
性狀	Solid
儲(chǔ)藏條件 Storage conditions	-20°C Freezer

BPH-715(1059677-23-4)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

BPH-715(1059677-23-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:BPH-715(1059677-23-4),BPH-715試劑,BPH-715的純度,BPH-715抑制劑,BPH-715的雜質(zhì),BPH-715的作用,BPH-715的合成,BPH-715的外觀,BPH-715的性質(zhì),BPH-715的廠家,BPH-715的生產(chǎn),BPH-715的MSDS,BPH-715的使用

產(chǎn)品說(shuō)明	BPH-715(1059677-23-4)用作抗癌劑，可阻止蛋白質(zhì)異戊二烯化，BPH-715也具有針對(duì)瘧原蟲(chóng)肝階段的有效活性。
Introduction	BPH-715 (1059677-23-4) is used as an anti-cancer agent to prevent protein prenylation. BPH-715 also has effective activity against the liver stage of Plasmodium.
Application1	BPH715 is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages.
Application2	BPH715 is also used to treat bone resorption diseases and has activity against a broad range of protists.
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)

Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation(Journal of medicinal chemistry,2008)

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth PMID 20457823; Antimicrobial agents and chemotherapy 2010 Jul; 54(7):2987-93

Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Singh AP;Zhang Y;No JH;Docampo R;Nussenzweig V;Oldfield E Antimicrob Agents Chemother. 2010 Jul;54(7):2987-93. doi: 10.1128/AAC.00198-10. Epub 2010 May 10.
Abstract:Nitrogen-containing bisphosphonates, drugs used to treat bone resorption diseases, also have activity against a broad range of protists, including blood-stage Plasmodium spp. Here, we show that new-generation "lipophilic" bisphosphonates designed as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages, with a high (>100) therapeutic index. Treatment of mice with the bisphosphonate BPH-715 and challenge with Plasmodium berghei sporozoites revealed complete protection (no blood-stage parasites after 28 days). There was also activity against blood-stage forms in vitro and a 4-day delay in the prepatent period in vivo. The lipophilic bisphosphonates have activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. The most active inhibitor in vitro and in vivo had enzyme inhibitory activity similar to that of the other, less active compounds but was more lipophilic. Lipophilic bisphosphonates are thus promising leads for novel antimalarials that target liver-stage infection.

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