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Bephenium

NMR下載 COA and HPLC MSDS下載
names：
Bephenium
CAS號(hào)：
7181-73-9
MDL Number：
MF(分子式)： C17H22NO MW(分子量)： 256.36
EINECS:230-546-7 Reaxys Number:
Pubchem ID:19667 Brand:BIOFOUNT

Bephenium(7181-73-9)又稱為羥萘酸芐酚寧或滅蟲寧：滅蟲寧為黃綠色結(jié)晶性粉末。熔點(diǎn)170-171℃，略溶于乙醇，不溶于不和乙醚。無臭，味苦。Bephenium是一種驅(qū)蟲藥。Bephenium也是B型乙酰膽堿受體激活劑。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000848-500mg	500mg	>95%	￥ 810.00	￥ 810.00		Backorder	- +	￥ 0.00
YZM000848-100mg	100mg	>95%	￥ 488.00	￥ 488.00		Backorder	- +	￥ 0.00

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中文別名	Bephenium(7181-73-9)
英文別名	Bephenium,7181-73-9
CAS號(hào)	7181-73-9
Inchi	InChI=1S/C17H22NO/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17/h3-12H,13-15H2,1-2H3/q+1
InchiKey	AVWWVJUMXRXPNF-UHFFFAOYSA-N
分子式 Formula	C17H22NO
分子量 Molecular Weight	256.36
溶解度Solubility
性狀	黃綠色結(jié)晶性粉末
儲(chǔ)藏條件 Storage conditions	請(qǐng)根據(jù)產(chǎn)品建議的存儲(chǔ)條件進(jìn)行存儲(chǔ),Please store the product under the recommended condition sin the description.

Bephenium(7181-73-9)毒性測(cè)試：

生物	測(cè)試類型	路線	報(bào)告劑量（標(biāo)準(zhǔn)化劑量）	影響	參考
mouse	LD50	oral	7880 mg/kg (7880 mg/kg)		British Journal of Pharmacology and Chemotherapy., 17(321), 1961 [PMID:13873487]

Bephenium(7181-73-9)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

Bephenium(7181-73-9)Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	Bephenium(7181-73-9)是一種驅(qū)蟲藥。Bephenium也是B型乙酰膽堿受體激活劑。
Introduction	Bephenium (7181-73-9) is an anthelmintic. Bephenium is also a type B acetylcholine receptor activator.
Application1	Bephenium(7181-73-9)為廣譜抗腸蟲產(chǎn)品，對(duì)鉤蟲、蛔蟲、鞭蟲病均有效。
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors(2012-06-01,PMID號(hào):22526556)

Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans(2011-03-01,PMID號(hào):21195075)

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum

Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds

Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors.
Charvet CL1, Robertson AP, Cabaret J, Martin RJ, Neveu C. Invert Neurosci. 2012 Jun;12(1):43-51. doi: 10.1007/s10158-012-0130-0. Epub 2012 Apr 24.
Abstract:Acetylcholine receptors (AChRs) are pentameric ligand-gated ion channels involved in the neurotransmission of both vertebrates and invertebrates. A number of anthelmintic compounds like levamisole and pyrantel target the AChRs of nematodes producing spastic paralysis of the worms. The muscle AChRs of nematode parasites fall into three pharmacological classes that are preferentially activated by the cholinergic agonists levamisole (L-type), nicotine (N-type) and bephenium (B-type), respectively. Despite a number of studies of the B-type AChR in parasitic species, this receptor remains to be characterized at the molecular level. Recently, we have reconstituted and functionally characterized two distinct L-AChR subtypes of the gastro-intestinal parasitic nematode Haemonchus contortus in the Xenopus laevis oocyte expression system by providing the cRNAs encoding the receptor subunits and three ancillary proteins (Boulin et al.

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