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AWZ1066S

NMR下載 COA and HPLC MSDS下載
names：
AWZ1066S
CAS號：
2239272-16-1
MDL Number：
MF(分子式)： C19H19F3N6O MW(分子量)： 404.39
EINECS: Reaxys Number:
Pubchem ID:135240137 Brand:BIOFOUNT

AWZ1066S(2239272-16-1)是一種對沃爾巴克氏菌有著高度特異性抗性的產(chǎn)品，可于用絲蟲病的短期研究。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000806-10mg	10mg	98.6%	￥ 5568.00	￥ 5568.00		2-3天	- +	￥ 0.00
YZM000806-5mg	5mg	98.6%	￥ 3412.00	￥ 3412.00		2-3天	- +	￥ 0.00

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中文別名	AWZ1066S(2239272-16-1)
英文別名	AWZ1066S,2239272-16-1
CAS號	2239272-16-1
Inchi	InChI=1S/C19H19F3N6O/c1-12-11-29-9-8-28(12)18-26-16-14(5-3-7-24-16)17(27-18)25-10-13-4-2-6-23-15(13)19(20,21)22/h2-7,12H,8-11H2,1H3,(H,24,25,26,27)/t12-/m0/s1
InchiKey	IZFVCNUAPFSNCO-LBPRGKRZSA-N
分子式 Formula	C19H19F3N6O
分子量 Molecular Weight	404.39
溶解度Solubility	生物體外In Vitro:DMSO溶解度125 mg/mL(309.11 mM;Need ultrasonic)
性狀	白色至灰白色固體粉末
儲藏條件 Storage conditions	存放在陰涼干燥處，短期（數(shù)天至數(shù)周）在0-4℃，長期（數(shù)月至數(shù)年）在-20℃。

AWZ1066S(2239272-16-1)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

AWZ1066S(2239272-16-1) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	AWZ1066S(2239272-16-1)是一種對沃爾巴克氏菌有著高度特異性抗性的產(chǎn)品，可于用絲蟲病的短期研究。
Introduction	AWZ1066S (2239272-16-1) is a product with high specific resistance to Wolbachia and can be used for short-term research on filariasis.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis
Abstract:Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting >90% of the essential nematode endosymbiont bacterium, Wolbachia, using antibiotics, can lead to permanent sterilization of adult female parasites and a safe macrofilaricidal outcome. AWZ1066S is a highly specific anti-Wolbachia candidate selected through a lead optimization program focused on balancing efficacy, safety and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic screening. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclinical models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate molecule is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.

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MSDS

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SDS 1.0 英文

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