艾默德斯

NMR下載 COA and HPLC MSDS下載
names：
Emodepside
CAS號：
155030-63-0
MDL Number： MFCD09837720
MF(分子式)： C60H90N6O14 MW(分子量)： 1119.39
EINECS:No data available Reaxys Number:155030-63-0
Pubchem ID:5293825 Brand:BIOFOUNT

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000789-10mg	10mg	>98.0%	￥ 2835.00	￥ 2835.00		2-3天	- +	￥ 0.00
YZM000789-5mg	5mg	>98.0%	￥ 1755.00	￥ 1755.00		2-3天	- +	￥ 0.00

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中文別名	艾默德斯(Emodepside,155030-63-0)
英文別名	Emodepside(艾默德斯,155030-63-0）
CAS號	155030-63-0
Inchi	InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1
InchiKey	ZMQMTKVVAMWKNY-YSXLEBCMSA-N
分子式 Formula	C60H90N6O14
分子量 Molecular Weight	1119.39
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 31 mg/mL(27.69 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

艾默德斯(Emodepside,155030-63-0)毒性：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	unreported	> 1600mg/kg (1600mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.
mouse	LD50	unreported	> 6400mg/kg (6400mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.
rat	LD50	unreported	> 6400mg/kg (6400mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.

艾默德斯(Emodepside,155030-63-0)物理性質(zhì)：

Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	253 dec	deg C		EXP
log P (octanol-water)	1.630	(none)		EST
Atmospheric OH Rate Constant	1.07E-10	cm3/molecule-sec	25	EST

艾默德斯(Emodepside,155030-63-0)實驗注意事項：
1.實驗前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	它具有殺蟲藥的作用。它是半合成衍生物和環(huán)八肽肽。
Introduction	Emodepside (PF 102221) is a cyclooctadepsipeptide with broadpectrum anthelmintic activity.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實驗過程中防止吸入、食入，做好安全防護(hù)

Worms take to the slo lane: a perspective on the mode of action of emodepside Invertebrate Neuroscience 2012/PMID: 22539031

Mechanisms of action of emodepside Parasitology Research 2005/PMID: 16228263

Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats Parasitology Research 2005/PMID: 16228275

Field evaluation of the efficacy and safety of emodepside/praziquantel spot–on solution against naturally acquired nematode and cestode infections in domestic cats Parasitology Researc/PMID: 16228276

Field Evaluation of the Efficacy and Safety of Emodepside plus Praziquantel Tablets (Profender? Tablets for Dogs) against Naturally Acquired Nematode and Cestode Infections in Dogs Par/PMID: 19575222

Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs

Abstract

This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs. Three randomised, blinded and controlled laboratory studies with naturally or experimentally infected dogs were performed. The first study was conducted as a dose determination study in experimentally infected dogs using three different dose levels, i.e., 0.5x, 1x and 2x the minimum therapeutic dose. Two further studies confirmed the efficacy of emodepside plus praziquantel tablets against mature and immature adult T. vulpis at the recommended minimum dose. In all three studies, the efficacy against mature and immature adult T. vulpis was >99%. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature adult stages of T. vulpis in dogs.

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