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葉綠素銅鈉

NMR下載 COA and HPLC MSDS下載
names：
Sodium copper chlorophyllin B
CAS號：
28302-36-5
MDL Number： No data available
MF(分子式)： C34H29CuN4Na3O7 MW(分子量)： 738.13
EINECS:247-608-4 Reaxys Number:No data available
Pubchem ID:135116291 Brand:BIOFOUNT

葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)對流感病毒和HIV發(fā)揮抗病毒活性，葉綠素銅鈉的IC₅₀s值都是50到100μM。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000656-1g	1g	>95%	￥ 506.00	￥ 506.00		2-3天	- +	￥ 0.00
YZM000656-500mg	500mg	>97%	￥ 390.00	￥ 390.00		2-3天	- +	￥ 0.00

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中文別名	葉綠素銅鈉(28302-36-5);銅酸鹽（3-），[（7S，8S）-3-羧基-5-（羧甲基）-13-乙烯基-18-乙基-17-甲?；? 7、8-二氫，2、8、12-三甲基-21H，23H-嗎啡-7-丙（5-）-κN21，κN22，κN23 ，κN24]-，鈉（1：3）;
英文別名	Sodium copper chlorophyllin B(28302-36-50);SodiuM Copper Chlorophyllin;SodiuM Copper Chlorophyllin;copper,trisodium,3-[(2S,3S)-20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;
CAS號	28302-36-5
Inchi	InChI = 1S / C34H34N4O7.Cu.3Na / c1-6-18-15（3）23-11-24-16（4）20（8-9-29（40）41）32（37-24）21（ 10-30（42）43）33-31（34（44）45）17（5）25（38-33）12-27-19（7-2）22（14-39）28（36-27） 13-26（18）35-23 ;;;; / h6,11-14,16,20H，1,7-10H2,2-5H3，（H5,35,36,37,38,39,40,41 ，42,43,44,45）;;; / q; +2; 3 * + 1 / p-5 / t16-，20-;;;; / m0 .... / s1
InchiKey	KYLOFEQLMQEHBO-JOKPRTCASA-I
分子式 Formula	C34H29CuN4Na3O7
分子量 Molecular Weight	738.13
溶解度Solubility	生物體外In Vitro:H2O : 10 mg/mL(13.55 mM;Need ultrasonic)DMSO溶解度6.67 mg/mL(9.04 mM;Need ultrasonic)
性狀	綠色至黑色粉末,Power
儲藏條件 Storage conditions	2-8oC,-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：葉綠素銅鈉試劑,葉綠素銅鈉雜質(zhì),葉綠素銅鈉中間體,葉綠素銅鈉密度,葉綠素銅鈉溶解度,葉綠素銅鈉旋光度,葉綠素銅鈉合成,葉綠素銅鈉閃點(diǎn),葉綠素銅鈉購買,葉綠素銅鈉MSDS,

產(chǎn)品說明	葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)對流感病毒和HIV發(fā)揮抗病毒活性,其IC50s 值都是 50 到 100 μM
Introduction	葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)exertsantiviralactivities againstInfluenza virusandHIVwithIC50s of50 to 100μM for both of them.
Application1	葉綠素B銅鈉對流感病毒和HIV發(fā)揮抗病毒活性，其IC50s值都是50到100μM。
Application2
Application3

葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)藥理學(xué):

※葉綠酸銅納主要含銅葉綠素銅鈉（三鈉）和葉綠素銅鈉（二鈉）。性質(zhì)：粉末狀墨綠色，易溶于水。來源：菠菜為原料，用現(xiàn)代的生物技術(shù)提取而成的天然色素。用途作為醫(yī)藥原料，可促進(jìn)胃腸潰瘍面的愈合，還可用于急慢性肝炎及肝炎引起的肝腫大、肝硬化、促進(jìn)肝功能恢復(fù)；作為食品著色劑。

※葉綠酸銅納在200 µM時(shí)表現(xiàn)出流感病毒吸附（P <0.05）。集成電路₅₀ 和50％的細(xì)胞毒性濃度（CC₅₀）葉綠素銅鈉鹽的濃度分別為50至100 µM和200至400 µM。葉綠素B銅鈉鹽還以2.5 mM抑制HIV吸附（P <0.05）。集成電路₅₀ 和CC₅₀ 的葉綠素銅鈉鹽濃度分別為50至100 µM和200至400 µM.

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Akiko Ito, et al. In Vitro Inhibition of Cytopathic Effect of Influenza Virus and Human Immunodeficiency Virus by Bamboo Leaf Extract Solution and Sodium Copper Chlorophyllin. Yonago Acta Med. 2016 Ma

葉綠素銅鈉(28302-36-5,Sodium copper chlorophyllin B)參考文獻(xiàn)：

1.Fighting fish parasites with photodynamically active chlorophyllin.
Häder DP1, Schmidl J2, Hilbig R3, Oberle M4, Wedekind H4, Richter P5. Parasitol Res. 2016 Mar 3. [Epub ahead of print]

Water-soluble chlorophyll (chlorophyllin) was used in a phototoxic reaction against a number of fish ectoparasites such as Ichtyobodo, Dactylogyrus, Trichodina, and Argulus. Chlorophyllin is applied to the water at concentrations of several micrograms per milliliter for a predefined incubation time, and afterwards, the parasites are exposed to simulated solar radiation. Application in the dark caused only little damage to the parasites; likewise, light exposure without the addition of the photosensitizer was ineffective. In Ichthyobodo, 2 μg/mL proved sufficient with subsequent simulated solar radiation to almost quantitatively kill the parasites, while in Dactylogyrus, a concentration of about 6 μg/mL was necessary. The LD50 value for this parasite was 1.02 μg/mL. Trichodina could be almost completely eliminated at 2 μg/mL. Only in the parasitic crustacean Argulus, no killing could be achieved by a photodynamic reaction using chlorophyllin.

2.??Topical Treatment With Liposomal Sodium Copper Chlorophyllin Complex in Subjects With Facial Redness and Erythematotelangiectatic Rosacea: Case Studies.
Vasily DB. J Drugs Dermatol. 2015 Oct;14(10):1157-9.

Physicians are often presented with patients complaining of facial redness and difficult to control rosacea. The water soluble sodium copper chlorophyllin complex has been shown to have anti-oxidant, anti-inflammatory, and anti-bacterial activities in vitro and anti-redness, pore reduction, and anti-acne activities in pilot clinical studies. In these case studies, the safety and efficacy of a topical gel containing a liposomal suspension of sodium copper chlorophyllin complex was assessed in subjects with facial redness and erythematotelangiectatic rosacea.

3.Roles of chlorophyllin in cell proliferation and the expression of apoptotic and cell cycle genes in HB4a non-tumor breast cells.
D Epiro GF1, Semprebon SC1, Niwa AM1, Marcarini JC2, Mantovani MS1. Toxicol Mech Methods. 2016 Apr 21:1-7. [Epub ahead of print]

Chlorophyllin (Chl) has attracted interest in the scientific community due to its chemopreventive and antimutagenic properties. However, the molecular mechanisms of action of Chl remain unclear. This study assesses the effects on cell proliferation and the expression of genes involved in apoptosis, and the cell cycle in HB4a cells treated with Chl. Chl was cytotoxic and induced apoptosis to HB4a cells at 400 μg/mL. Analysis of gene expression showed that there was a decrease in the mRNA level of BIRC5 and CCNA2 genes involved in apoptosis and cell cycle progression, respectively. The proapoptotic gene BAX and the antiapoptotic genes BCL-2 and BCL-XL were upregulated. The cytotoxicity of Chl has been attributed to increases in the expression of BAX and decreases in the expression of genes involved in the cell cycle, but increases in the expression of anti-apoptotic genes suggests a mechanism for protection from cell death induced by Chl. This study provides important information about mechanisms that protect against or trigger damaging processes in non-tumor cells.

4.Treatment of ichthyophthiriasis with photodynamically active chlorophyllin.
Häder DP1, Schmidl J2, Hilbig R3, Oberle M4, Wedekind H4, Richter PR5. Parasitol Res. 2016 Apr;115(4):1509-17. doi: 10.1007/s00436-015-4884-2. Epub 2015 Dec 23.

Water-soluble chlorophyll (chlorophyllin) exerts pronounced photodynamic activity on fish parasites. In order to determine its potential as a remedy against ectoparasites in fish carps were incubated in water with defined concentrations of chlorophyllin. The main focus of the experiments was on the ciliate Ichthyophthirius multifiliis (Fouquet) which is responsible for considerable losses in livestock in aquaculture. As malachite green, which in the past efficiently cured infected fishes, is banned because of its possible carcinogenicity; no effective remedy is presently available in aquaculture to treat ichthyophthiriasis. Using chlorophyllin, the number of trophonts was significantly reduced (more than 50 %) after 3 h incubation of infested fish at 2 and 4 mg/L and subsequent irradiation with simulated solar radiation. The lack of reinfection after light treatment indicates that also the remaining parasites have lost their multiplication capacity.

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