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克拉夫定

NMR下載 COA and HPLC MSDS下載
names：
Clevudine
CAS號：
163252-36-6
MDL Number： MFCD00935785
MF(分子式)： C10H13FN2O5 MW(分子量)： 260.22
EINECS: Reaxys Number:
Pubchem ID:73115 Brand:BIOFOUNT

克拉夫定(Clevudine,163252-36-6)是一種合成的嘧啶類似物，對乙型肝炎病毒（HBV）具有活性。在細(xì)胞內(nèi)，克列夫定被磷酸化為其活性代謝產(chǎn)物，克拉夫定單磷酸鹽和三磷酸鹽。三磷酸代謝物與胸苷競爭并入病毒DNA中，從而導(dǎo)致DNA鏈終止并抑制HBV DNA聚合酶（逆轉(zhuǎn)錄酶）的功能。克拉夫定具有長的半衰期，并且顯示出共價(jià)閉合的環(huán)狀DNA（cccDNA）的顯著減少.

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000536-50mg	50mg	99.95%	￥ 6874.00	￥ 6874.00		2-3天	- +	￥ 0.00
YZM000536-10mg	10mg	99.95%	￥ 2184.00	￥ 2184.00		2-3天	- +	￥ 0.00

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中文別名	克拉夫定(cas:163252-36-6),1-(2'-脫氧-2'-氟-L-阿拉伯呋喃糖基)-5-甲基尿嘧啶
英文別名	Clevudine(cas:163252-36-6),Levovir,L-FMAU,Clevudine (Levovir)
CAS號	163252-36-6
Inchi	InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1
InchiKey	GBBJCSTXCAQSSJ-XQXXSGGOSA-N
分子式 Formula	C10H13FN2O5
分子量 Molecular Weight	260.22
溶解度Solubility	生物體外In Vitro:DMSO溶解度≥ 50 mg/mL(192.15 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Clevudine(CAS:163252-36-6)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	克拉夫定(Clevudine,163252-36-6)是嘧啶2'-脫氧核糖核苷?？死蚨ㄈ芙舛?克拉夫定MSDS詳見主頁。
Introduction	Clevudine (克拉夫定,163252-36-6)is a pyrimidine 2'-deoxyribonucleoside.
Application1	udine是一種合成的嘧啶類似物，對乙型肝炎病毒（HBV）具有活性。在細(xì)胞內(nèi)，克列夫定被磷酸化為其活性代謝產(chǎn)物，克列夫定單磷酸鹽和三磷酸鹽。
Application2	克列夫定具有長的半衰期
Application3

克拉夫定(Clevudine,163252-36-6)brief：
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA)

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy Journal of Gastroenterology 2010

A comparison of clevudine and entecavir for treatment-na?ve patients with chronic hepatitis B: results after 2 years of treatment Hepatology International 2012

A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-na?ve patients with chronic hepatitis B Hepatology International 2010

Monofluorinated Heterocycles Halogenated Heterocycles 2011

2013-09-01 Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine Antimicrobial agents and chemotherapy

其他文獻(xiàn)：
1. 2013-09-01   Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine   Antimicrobial agents and chemotherapy
2. 2012-10-01   Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU)   Nuclear medicine and biology
3. 2012-09-01   [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations   Molecular imaging
4. 2012-04-01   Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry   Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
5. 2012-04-01   [New drugs of treatment of patients with chronic hepatitis B]   Nihon rinsho. Japanese journal of clinical medicine

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