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Levoketoconazole

NMR下載 COA and HPLC MSDS下載
names：
(-)-Ketoconazole
CAS號：
142128-57-2
MDL Number：
MF(分子式)： C26H28Cl2N4O4 MW(分子量)： 531.43
EINECS:265-667-4 Reaxys Number:
Pubchem ID:47576 Brand:BIOFOUNT

Levoketoconazole(cas:142128-57-2)是苯基哌嗪的合成衍生物，具有廣泛的抗真菌特性和潛在的抗腫瘤活性。Levoketoconazole抑制固醇14-α-二甲基酶（一種微粒體細胞色素P450依賴性酶），從而破壞了麥角固醇（真菌細胞壁的重要組成部分）的合成。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數量	總計 (￥)
YZM000461-50mg	50mg	99.4%	￥ 3543.00	￥ 3543.00		1-3天	- +	￥ 0.00
YZM000461-10mg	10mg	99.4%	￥ 975.00	￥ 975.00		1-3天	- +	￥ 0.00

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中文別名	Levoketoconazole(cas:142128-57-2)
英文別名	Levoketoconazole(cas:142128-57-2),(-)-Ketoconazole,Nizoral,ketoconazole, Ketoderm
CAS號	142128-57-2
Inchi	InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InchiKey	XMAYWYJOQHXEEK-ZEQKJWHPSA-N
分子式 Formula	C26H28Cl2N4O4
分子量 Molecular Weight	531.43
溶解度Solubility	生物體外In Vitro:DMSO溶解度33.33 mg/mL(62.72 mM;Need ultrasonic)
性狀	固體粉末,Power
儲藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Levoketoconazole(cas:142128-57-2)毒理性質:

方法	系統(tǒng)	動物	劑量	影響	日期
Mutation Data	DNA Damage	liver/human	1 mmol/l/48H		March 2019
Mutation Data	DNA inhibition	lymphocyte/human	10 mg/L		March 2019
Mutation Data	DNA inhibition	other cell types/human	1 µmol/L		March 2019
Reproductive Effects		oral/man	1029 mg/kg (60D male)	Reproductive: Other effects on male; Endocrine: Androgenic	March 2019
Reproductive Effects		oral/rat	6480 mg/kg (9W male/2W pre-7D pregnant)	Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles); Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	March 2019
Reproductive Effects		oral/rat	600 mg/kg (3D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count); Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	March 2019
Reproductive Effects		oral/rat	3240 mg/kg (9W male/2W pre-7D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea); Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	March 2019
Reproductive Effects		oral/rat	880 mg/kg (7-17D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth); Reproductive: Effects on embryo or fetus: Fetal death; Reproductive: Specific developmental abnormalities: Musculoskeletal system	March 2019
Reproductive Effects		oral/rat	1040 mg/kg (17-21D preg/21D after birth)	Reproductive: Maternal effects: Parturition; Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	March 2019
Reproductive Effects		oral/rat	300 mg/kg (1D male)	Reproductive: Other effects on male	March 2019

(-)-Ketoconazole(CAS:142128-57-2)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質及有害物質產生，必要時實驗操作需要手套箱內完成以免對實驗人員造成傷害
3.實驗后產生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產品說明	Levoketoconazole(142128-57-2)（-）-酮康唑（（-）-R 41400）是酮康唑的對映異構體之一。
Introduction	Levoketoconazol(142128-57-2) is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R))etoconazole) and dextroketoconazole ((2R,4S)+)etoconazole).
Application1
Application2
Application3

Levoketoconazole(142128-57-2)-）-酮康唑（（-）-R 41400）是酮康唑的對映異構體之一。酮康唑是兩種對映體的外消旋混合物，左酮康唑（（2S，4R）-（）-酮康唑）和右酮康唑（（2R，4S）-（+）-酮康唑）。

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護