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帕珠沙星,Pazufloxacin(CAS:127045-41-4)毒理性質(zhì)：

生物	測試類型	路線	劑量	影響	參考
rat	LD	oral	>5 gm/kg (5000 mg/kg)		Chemotherapy, 43(Suppl
rat	LD	subcutaneous	>5 gm/kg (5000 mg/kg)	SKIN AND APPENDAGES (SKIN): DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
rat	LD50	intravenous	341 mg/kg (341 mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
mouse	LD	oral	>5 gm/kg (5000 mg/kg)		Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
mouse	LD50	intravenous	783 mg/kg (783 mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; LUNGS, THORAX, OR RESPIRATION: DYSPNEA; SKIN AND APPENDAGES (SKIN): DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
dog	LD	oral	>2 gm/kg (2000 mg/kg)		Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]
dog	LDLo	intravenous	400 mg/kg (400 mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; GASTROINTESTINAL: NAUSEA OR VOMITING	Japanese Journal of Antibiotics., 48(754), 1995 [PMID:7666580]

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Pazufloxacin 功能研究：
Pazufloxacin，T-3761在小鼠中對革蘭氏陽性和革蘭氏陰性細菌（包括對喹諾酮耐藥的粘質(zhì)沙雷氏菌和銅綠假單胞菌）的全身，肺和泌尿道感染表現(xiàn)出良好的功效。T-3761在小鼠中對大多數(shù)感染模型的體內(nèi)活性與氧氟沙星，環(huán)丙沙星，諾氟沙星和托氟沙星的體內(nèi)活性相當或更高。T-3761對小鼠革蘭氏陽性細菌的全身和肺部感染的活性低于托沙沙星，但對耐甲氧西林的金黃色葡萄球菌的感染卻沒有活性[1]。T-3761具有廣泛的活性，并且對革蘭氏陽性和陰性細菌具有有效的活性。T-3761對90％的對甲氧西林敏感的金黃色葡萄球菌，對甲氧西林敏感.

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帕珠沙星,Pazufloxacin(CAS:127045-41-4)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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