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頭孢地嗪鈉

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names：
Cefodizime Sodium
CAS號(hào)：
86329-79-5
MDL Number： MFCD00897059
MF(分子式)： C20H18N6Na2O7S4 MW(分子量)： 628.63
EINECS:Not available Reaxys Number:Not available
Pubchem ID:9852176 Brand:BIOFOUNT

頭孢地嗪鈉(CefodizimeSodium,86329-79-5)是一種第三代頭孢菌素抗生素，具有廣泛的抗菌活性。Cefodizime sodium 對(duì)腎臟沒(méi)有毒性，具有良好的耐受性和免疫調(diào)節(jié)活性，可用于呼吸道和泌尿道的嚴(yán)重感染的研究。

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中文別名	頭孢地嗪鈉(86329-79-5),頭孢地嗪二鈉,頭孢地嗪二鈉鹽,頭孢噻肟二鈉,
英文別名	CefodizimeSodium(86329-79-5),CEFODIZIME DISODIUM,Cefodizime disodium salt,thr-221; HR 221;
CAS號(hào)	86329-79-5
Inchi	InChI=1S/C20H20N6O7S4.2Na/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9;;/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32);;/q;2*+1/p-2/b25-12-;;/t13-,17-;;/m1../s1
InchiKey	WBOBLQIRACJNPA-AEKYOGSZSA-L
分子式 Formula	C20H18N6Na2O7S4
分子量 Molecular Weight	628.63
溶解度Solubility
性狀	powder
儲(chǔ)藏條件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

頭孢地嗪鈉(CefodizimeSodium,86329-79-5)毒理性質(zhì)：

生物	測(cè)試類型	路線	劑量	影響	參考
rat	LDLo	oral	20 gm/kg (20000 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); LUNGS, THORAX, OR RESPIRATION: CYANOSIS; GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA	Journal of Toxicological Sciences., 13(Suppl
rat	LD50	intraperitoneal	8800 mg/kg (8800 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
rat	LD50	subcutaneous	15500 mg/kg (15500 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
rat	LD50	intravenous	7 gm/kg (7000 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
mouse	LD50	oral	28 gm/kg (28000 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); LUNGS, THORAX, OR RESPIRATION: CYANOSIS; GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA	Journal of Toxicological Sciences., 13(Suppl
mouse	LD50	intraperitoneal	10500 mg/kg (10500 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
mouse	LD50	subcutaneous	16500 mg/kg (16500 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
mouse	LD50	intravenous	5 gm/kg (5000 mg/kg)	BRAIN AND COVERINGS: CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.); BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicological Sciences., 13(Suppl
dog	LD50	intravenous	>5 gm/kg (5000 mg/kg)		Drugs in Japan, -(667), 1995

頭孢地嗪鈉(CefodizimeSodium,86329-79-5)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說(shuō)明	頭孢地嗪鈉(86329-79-5,CefodizimeSodium)可以作為藥物雜質(zhì)對(duì)照品以及生物醫(yī)藥類試劑。
Introduction	CefodizimeSodium(頭孢地嗪鈉,86329-79-5)can be used as a reference substance for drug impurities and reagents，only for research.
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警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303+H313+H333
安全防護(hù)	P264+P280+P305+P351+P338+P337+P313
備注	實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù)