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KKL-35

NMR下載 COA and HPLC MSDS下載
names：
KKL-35
CAS號：
865285-29-6
MDL Number： MFCD04438597
MF(分子式)： C15H9ClFN3O2 MW(分子量)： 317.7
EINECS: Reaxys Number:
Pubchem ID:4128171 Brand:BIOFOUNT

KKL-35(865285-29-6)是一種翻譯標(biāo)記反應(yīng)抑制劑（IC50 = 0.9 µM），因此可通過阻止核糖體拯救來抑制細(xì)菌生長。

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫存描述	數(shù)量	總計(jì) (￥)
YZM000160-1mg	1mg	99.42%	￥ 2925.00	￥ 2925.00		2-3天	- +	￥ 0.00

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中文別名	KKL-35(865285-29-6);KKL-35；KKL 35; KKL35; 4-氯-N- [5-（4-氟苯基）-1,3,4-惡二唑-2-基]苯甲酰胺; F1374-0110；4-氯-N-（5-（4-氟苯基）-1,3,4-惡二唑-2-基）苯甲酰胺;
英文別名	KKL-35(865285-29-6);KKL-35; KKL 35; KKL35; 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide; F1374-0110; 4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide;
CAS號	865285-29-6
Inchi	InChI=1S/C15H9ClFN3O2/c16-11-5-1-9(2-6-11)13(21)18-15-20-19-14(22-15)10-3-7-12(17)8-4-10/h1-8H,(H,18,20,21)
InchiKey	ZIICPNCCHIUJSX-UHFFFAOYSA-N
分子式 Formula	C15H9ClFN3O2
分子量 Molecular Weight	317.7
溶解度Solubility	生物體外In Vitro:DMSO溶解度6.25 mg/mL(19.67 mM;Need ultrasonic)
性狀	white to beige powder
儲藏條件 Storage conditions	2-8°C，-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

KKL-35(865285-29-6)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:KKL-35試劑,KKL-35雜質(zhì),KKL-35中間體,KKL-35密度,KKL-35溶解度,KKL-35抑制劑,KKL-35閃點(diǎn),KKL-35熔點(diǎn),KKL-35購買,KKL-35結(jié)構(gòu)式,

產(chǎn)品說明	(865285-29-6)KKL-35是反式標(biāo)記反應(yīng)的抑制劑，IC50值是0.9 μM
Introduction	KKL-35(865285-29-6)is atransranslation tagging reactioninhibitor with anIC50of 0.9 μM.
Application1
Application2
Application3

KKL-35(865285-29-6)藥理學(xué)：

1、KKL-35是反式標(biāo)記反應(yīng)抑制劑，IC₅₀額定0.9 µM。

2、KKL-35具有廣譜抗生素活性。KKL-35可抑制炭疽芽孢桿菌和恥垢分枝桿菌的生長，其最小抑菌濃度（MIC）值應(yīng)小于6 µM。在標(biāo)記蛋白的蛋白水解之前，KKL-35會抑制翻譯的某個步驟。KKL-35抑制DHFR-ns的標(biāo)簽。在最高濃度的KKL-35的反應(yīng)中會產(chǎn)生大量未標(biāo)記的DHFR，這表明KKL-35不會抑制翻譯。WT的KKL-35防止生長弗氏志賀菌以6μM的MIC，并加入KKL-35到的生長培養(yǎng)弗氏志賀菌停止生長。在弗氏鏈球菌中表達(dá)ArfA并缺失ssrA的菌株，添加KKL-35對生存力或生長率幾乎沒有影響。KKL-35抑制小分子外排不足的大腸桿菌 ?tolC 的生長，MIC為0.3 µM。

警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)

KKL-35(865285-29-6)危害標(biāo)識：

象形圖
信號	Warning
GHS危險(xiǎn)說明	Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.
	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范說明代碼	P264, P270, P301+P312, P330, and P501
防范說明代碼	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Ramadoss NS, et al. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7.

KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition PMID 29158279; Antimicrobial agents and chemotherapy 2018 02; 62(2): Name matches: o

A Genetic Tool to Quantify trans-Translation Activity in Vivo PMID 29031699; Journal of molecular biology 2017 11; 429(23):3617-3625 Name matches: smpb kkl-35

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity PMID 23733947; Proceedings of the National Academy of Sciences of the United States of America 2013 Jun; 110(25):

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells PMID 28762275; ACS infectious diseases 2017 09; 3(9):634-644 Name matches: tuberculosis k

KKL-35(865285-29-6)參考文獻(xiàn)：

1.A Genetic Tool to Quantify trans-Translation Activity in Vivo.
Macé K;Demay F;Guyomar C;Georgeault S;Giudice E;Goude R;Trautwetter A;Ermel G;Blanco C;Gillet R J Mol Biol. 2017 Nov 24;429(23):3617-3625. doi: 10.1016/j.jmb.2017.10.007. Epub 2017 Oct 13.

In bacteria, trans-translation is the main quality control mechanism for rescuing ribosomes arrested during translation. This key process is universally conserved and plays a critical role in the viability and virulence of many pathogens. We developed a reliable in vivo double-fluorescence reporter system for the simultaneous quantification of both trans-translation and the associated proteolysis activities in bacteria. The assay was validated using mutant bacteria lacking tmRNA, SmpB, and the ClpP protease. Both antisense tmRNA-binding RNA and a peptide mimicking the SmpB C-terminal tail proved to be potent inhibitors of trans-translation in vivo. The double-fluorescent reporter was also tested with KKL-35, an oxadiazole derivative that is supposed to be a promising trans-translation inhibitor, and it surprisingly turns out that trans-translation is not the only target of KKL-35 in vivo.

2.KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of
Brunel R;Descours G;Durieux I;Doublet P;Jarraud S;Charpentier X Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb.

trans;-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit ;trans;-translation have been found to have broad-spectrum antibiotic activity. We sought to determine the activity of KKL-35, a potent member of the oxadiazole family, against the human pathogen ;Legionella pneumophila; and other related species that can also cause Legionnaires' disease (LD). Consistent with the essential nature of ;trans;-translation in ;L. pneumophila;, KKL-35 inhibited the growth of all tested strains at submicromolar concentrations. KKL-35 was also active against other LD-causing ;Legionella; species. KKL-35 remained equally active against ;L. pneumophila; mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of ;L. pneumophila; in human macrophages at several stages of infection. No resistant mutants could be obtained, even during extended and chronic exposure. Surprisingly, KKL-35 was not synergistic with other ribosome-targeting antibiotics and did not induce the filamentation phenotype observed in cells defective for ;trans;-translation. Importantly, KKL-35 remained active against ;L.

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