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PBTZ169

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names：
Macozinone
CAS號(hào)：
1377239-83-2
MDL Number：
MF(分子式)： C20H23F3N4O3S MW(分子量)： 456.48
EINECS: Reaxys Number:
Pubchem ID:57331386 Brand:BIOFOUNT

PBTZ169(cas:1377239-83-2)Macozinone is under investigation in clinical trial NCT03036163 (Phase 1 Study of PBTZ169).

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)
YZM000097-5mg	5mg	99.13%	￥ 1170.00	￥ 1170.00		2-3天	- +	￥ 0.00

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中文別名	PBTZ169(cas:1377239-83-2),PBTZ-169,PBTZ 169
英文別名	Macozinone(cas:1377239-83-2),PBTZ169,PBTZ-169
CAS號(hào)	1377239-83-2
Inchi	InChI=1S/C20H23F3N4O3S/c21-20(22,23)14-10-15-17(16(11-14)27(29)30)31-19(24-18(15)28)26-8-6-25(7-9-26)12-13-4-2-1-3-5-13/h10-11,13H,1-9,12H2
InchiKey	BJDZBXGJNBMCAV-UHFFFAOYSA-N
分子式 Formula	C20H23F3N4O3S
分子量 Molecular Weight	456.48
溶解度Solubility	生物體外In Vitro:DMSO溶解度6.4 mg/mL(14.02 mM;Need ultrasonic)
性狀	固體粉末,Power
儲(chǔ)藏條件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

PBTZ169(cas:1377239-83-2)Macozinone毒理性質(zhì):

動(dòng)物	測(cè)試類型	途徑	實(shí)驗(yàn)攝入量 (標(biāo)準(zhǔn)攝入量)	影響	文獻(xiàn)來源
chicken	LD50	intramuscular	432mg/kg (432mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
chicken	LD50	intravenous	48mg/kg (48mg/kg)	BEHAVIORAL: IRRITABILITY BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 15, Pg. 52, 1978.
chicken	LD50	oral	5400mg/kg (5400mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
chicken	LD50	subcutaneous	620mg/kg (620mg/kg)	BEHAVIORAL: IRRITABILITY BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 15, Pg. 52, 1978.
guinea pig	LD50	oral	> 1gm/kg (1000mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
mouse	LD50	intravenous	589mg/kg (589mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Food and Cosmetics Toxicology. Vol. 4, Pg. 1, 1966.
mouse	LD50	oral	> 6200mg/kg (6200mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
mouse	LD50	subcutaneous	1354mg/kg (1354mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 4, Pg. 1, 1966.
rat	LD50	intravenous	695mg/kg (695mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 4, Pg. 1, 1966.
rat	LD50	oral	> 6200mg/kg (6200mg/kg)		Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.

Macozinone(CAS:1377239-83-2)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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產(chǎn)品說明	PBTZ169(CAS:1377239-83-2)Macozinone 是一種有效的殺菌型苯并噻嗪酮，也是有效的DprE1的抑制劑,PBTZ169(cas:1377239-83-2)Macozinone is under investigation in clinical trial NCT03036163 (Phase 1 Study of PBTZ169).
Introduction	Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potentDprE1(decaprenylphosphorylibose 2′xidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the activeite Cys387 residue. Macozinone has antituberculosis effect[2].
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警示圖
危險(xiǎn)性	warning
危險(xiǎn)性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害
安全防護(hù)	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理
備注	實(shí)驗(yàn)過程中防止吸入、食入，做好安全防護(hù)