購(gòu)物車 
-
4-戊炔酸琥珀亞胺酯
- names：
Propargyl-C1-NHS ester
- CAS號(hào)：
132178-37-1
MDL Number： MFCD22577791 - MF(分子式)： C9H9NO4 MW(分子量)： 195.17
- EINECS: Reaxys Number:
- Pubchem ID:57339402 Brand:BIOFOUNT
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗體偶聯(lián)藥物 (ADC) 。
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|---|---|---|---|---|---|---|---|
| YZM001020-500mg | 500mg | 95% | ￥ 8560.00 | ￥ 8560.00 | 1-3days | ￥ 0.00 | ||
| YZM001020-100mg | 100mg | 95% | ￥ 2800.00 | ￥ 2800.00 | 1-3days | ￥ 0.00 |
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| 中文別名 | 4-戊炔酸琥珀亞胺酯(132178-37-1); |
| 英文別名 | Propargyl-C1-NHS ester(132178-37-1);2,5-dioxopyrrolidin-1-yl pent-4-ynoate;4-Pentynoic acid NHS ester;Propargyl-C1-NHS ester;PROPARGYL-C1-NHS ESTER;4-Pentynoic acid succinimidyl ester; |
| CAS號(hào) | 132178-37-1 |
| Inchi | InChI=1S/C9H9NO4/c1-2-3-4-9(13)14-10-7(11)5-6-8(10)12/h1H,3-6H2 |
| InchiKey | VLQOCPXVAZTWQR-UHFFFAOYSA-N |
| 分子式 Formula | C9H9NO4 |
| 分子量 Molecular Weight | 195.17 |
| 溶解度Solubility | |
| 性狀 | Solid |
| 儲(chǔ)藏條件 Storage conditions | 請(qǐng)根據(jù)產(chǎn)品建議的存儲(chǔ)條件進(jìn)行存儲(chǔ),Please store the product under the recommended condition sin the description. |
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)實(shí)驗(yàn)注意事項(xiàng)：
1.實(shí)驗(yàn)前需戴好防護(hù)眼鏡，穿戴防護(hù)服和口罩，佩戴手套，避免與皮膚接觸。
2.實(shí)驗(yàn)過(guò)程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時(shí)實(shí)驗(yàn)操作需要手套箱內(nèi)完成以免對(duì)實(shí)驗(yàn)人員造成傷害
3.實(shí)驗(yàn)后產(chǎn)生的廢棄物需分類存儲(chǔ)，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tags:32178-37-1試劑,32178-37-1雜質(zhì),32178-37-1合成,32178-37-1密度,32178-37-1溶解度,32178-37-1旋光度,32178-37-1閃點(diǎn),32178-37-1熔點(diǎn),32178-37-1購(gòu)買,32178-37-1MSDS,
| 產(chǎn)品說(shuō)明 | 4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker,可用于合成抗體偶聯(lián)藥物 (ADC) |
| Introduction | 4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)is a nonclaevable linker for antibodyrugonjugation (ADC). |
| Application1 | |
| Application2 | |
| Application3 |
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)藥理學(xué)：
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗體偶聯(lián)藥物 (ADC) 。
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)是一種不可降解的 linker，Propargyl-C1-NHS ester可用于合成抗體偶聯(lián)藥物 (ADC) 。
| 警示圖 | |
| 危險(xiǎn)性 | warning |
| 危險(xiǎn)性警示 | Not available |
| 安全聲明 | H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對(duì)身體有害 |
| 安全防護(hù) | P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護(hù)理 |
| 備注 | 實(shí)驗(yàn)過(guò)程中防止吸入、食入，做好安全防護(hù) |
| Bastian et al. Selective transformations of complex molecules are enabled by aptameric protective groups. Nature Chemistry, doi: 10.1038/nchem.1402, published online 22 July 2012 http://www.nature.com |
| Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872 |
| Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study Journal of Nanobiotechnology 2017 28982368 |
| Molecular Targeted Viral Nanoparticles as Tools for Imaging Cancer Virus Hybrids as Nanomaterials 2014 24243252 |
| Design and Modular Construction of a Polymeric Nanoparticle for Targeted Atherosclerosis Positron Emission Tomography Imaging: A Story of 25% 64Cu-CANF-Comb Pharmaceutical Research 2016 27286872 |
4-戊炔酸琥珀亞胺酯(132178-37-1,Propargyl-C1-NHS ester)參考文獻(xiàn)：
1、Selective transformations of complex molecules are enabled by aptameric protective groups
Andreas A. Bastian, Alessio Marcozzi & Andreas Herrmann
Abstract Emerging trends in drug discovery are prompting a renewed interest in natural products as a source of chemical diversity and lead structures. However, owing to the structural complexity of many natural compounds, the synthesis of derivatives is not easily realized. Here, we demonstrate a conceptually new approach using oligonucleotides as aptameric protective groups. These block several functionalities by non-covalent interactions in a complex molecule and enable the highly chemo- and regioselective derivatization (>99%) of natural antibiotics in a single synthetic step with excellent conversions of up to 83%. This technique reveals an important structure–activity relationship in neamine-based antibiotics and should help both to accelerate the discovery of new biologically active structures and to avoid potentially costly and cumbersome synthetic routes.
2、Preparation of Peptide and Other Biomolecular Conjugates Through Chemoselective Ligations
Mathieu GalibertOlivier RenaudetDidier BoturynPascal Dumy
Abstract The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne–azide cycloaddition (“click”) reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.
3、Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen & Jem-Kun Chen
Abstract In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures. In addition, the optimal operation window for DNA detection ranges from 0 to 0.2 M of NaCl concentration. Therefore, the specimens were prepared in the PBS solution at 150 mM NaCl concentration for target hybridization. The supramolecular complex state of the PNIPAAm-b-ssDNA copolymer brushes transformed into the phase-separated state after the hybridization with 0.5 ng/µL of its target DNA sequence owing to the competition between BMHBs and complementary hydrogen bonds. This phase transformation of the PNIPAAm and probe segments inhibited the proton transfer and significantly increased the resistivity at 25 °C. Moreover, there were no significant changes in the resistivity of the copolymer brushes after hybridization with the target sequence at 45 °C. These results indicated that the phase-separated state of the PNIPAAm-b-ssDNA copolymer brushes, which was generally occurred above the LCST, can be substantially generated after hybridization with its target DNA sequence. By performing the controlled experiments, in the same manner, using another sequence with lengths similar to that of the target sequence without complementarity. In addition, the sequences featuring various degrees of complementarity were exploited to verify the phase separation behavior inside the PNIPAAm-b-ssDNA copolymer thin film.
1、Selective transformations of complex molecules are enabled by aptameric protective groups
Andreas A. Bastian, Alessio Marcozzi & Andreas Herrmann
Abstract Emerging trends in drug discovery are prompting a renewed interest in natural products as a source of chemical diversity and lead structures. However, owing to the structural complexity of many natural compounds, the synthesis of derivatives is not easily realized. Here, we demonstrate a conceptually new approach using oligonucleotides as aptameric protective groups. These block several functionalities by non-covalent interactions in a complex molecule and enable the highly chemo- and regioselective derivatization (>99%) of natural antibiotics in a single synthetic step with excellent conversions of up to 83%. This technique reveals an important structure–activity relationship in neamine-based antibiotics and should help both to accelerate the discovery of new biologically active structures and to avoid potentially costly and cumbersome synthetic routes.
2、Preparation of Peptide and Other Biomolecular Conjugates Through Chemoselective Ligations
Mathieu GalibertOlivier RenaudetDidier BoturynPascal Dumy
Abstract The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne–azide cycloaddition (“click”) reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.
3、Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen & Jem-Kun Chen
Abstract In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures. In addition, the optimal operation window for DNA detection ranges from 0 to 0.2 M of NaCl concentration. Therefore, the specimens were prepared in the PBS solution at 150 mM NaCl concentration for target hybridization. The supramolecular complex state of the PNIPAAm-b-ssDNA copolymer brushes transformed into the phase-separated state after the hybridization with 0.5 ng/µL of its target DNA sequence owing to the competition between BMHBs and complementary hydrogen bonds. This phase transformation of the PNIPAAm and probe segments inhibited the proton transfer and significantly increased the resistivity at 25 °C. Moreover, there were no significant changes in the resistivity of the copolymer brushes after hybridization with the target sequence at 45 °C. These results indicated that the phase-separated state of the PNIPAAm-b-ssDNA copolymer brushes, which was generally occurred above the LCST, can be substantially generated after hybridization with its target DNA sequence. By performing the controlled experiments, in the same manner, using another sequence with lengths similar to that of the target sequence without complementarity. In addition, the sequences featuring various degrees of complementarity were exploited to verify the phase separation behavior inside the PNIPAAm-b-ssDNA copolymer thin film.
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