伊人激情av一区二区三区,国产日韩亚洲大尺度高清

GNF179 Metabolite

NMR下載 COA and HPLC MSDS下載
names：
GNF179 Metabolite
CAS號：
1310455-86-7
MDL Number： MFCD22690265
MF(分子式)： C14H16FN3 MW(分子量)： 245.3
EINECS: Reaxys Number:
Pubchem ID:57521783 Brand:BIOFOUNT

GNF179 Metabolite(1310455-86-7)是GNF179的代謝物，GNF179 Metabolite是一種經(jīng)過優(yōu)化的8,8-二甲基IP類似物，GNF179 Metabolite具有良好的體外代謝穩(wěn)定性和體內(nèi)口服生物相容性。

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
YZM000850-5mg	5mg	>95%	￥ 3295.00	￥ 3295.00		Backorder	- +	￥ 0.00
YZM000850-2mg	2mg	>95%	￥ 2116.00	￥ 2116.00		Backorder	- +	￥ 0.00

大包裝詢價提供各種包裝，敬請垂詢
收藏商品商品點評加入購物車立即購買

快速詢價

收起

你想詢價的產(chǎn)品

*產(chǎn)品名稱：

CAS號：

產(chǎn)品編號：

需求描述：

請準確填寫您的聯(lián)系方式，以便為您提供最好的服務(wù)。

*公司名稱：

*電子郵箱：

聯(lián)系人：

*電話：

*驗證碼：

詢價

中文別名	GNF179 Metabolite(1310455-86-7);GNF179代謝物;GNF179 (Metabolite);GNF-179 Metabolite
英文別名	GNF179 Metabolite,1310455-86-7
CAS號	1310455-86-7
Inchi	InChI=1S/C14H16FN3/c1-14(2)13-17-12(9-18(13)8-7-16-14)10-3-5-11(15)6-4-10/h3-6,9,16H,7-8H2,1-2H3
InchiKey	GZVLWGZMELYUPG-UHFFFAOYSA-N
分子式 Formula	C14H16FN3
分子量 Molecular Weight	245.3
溶解度Solubility
性狀	Solid
儲藏條件 Storage conditions	請根據(jù)產(chǎn)品建議的存儲條件進行存儲,Please store the product under the recommended condition sin the description.

GNF179 Metabolite(1310455-86-7)實驗注意事項：
1.實驗前需戴好防護眼鏡，穿戴防護服和口罩，佩戴手套，避免與皮膚接觸。
2.實驗過程中如遇到有毒或者刺激性物質(zhì)及有害物質(zhì)產(chǎn)生，必要時實驗操作需要手套箱內(nèi)完成以免對實驗人員造成傷害
3.實驗后產(chǎn)生的廢棄物需分類存儲，并交于專業(yè)生物廢氣物處理公司處理，以免造成環(huán)境污染

GNF179 Metabolite(1310455-86-7) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:GNF179 Metabolite(1310455-86-7),GNF179 Metabolite試劑,GNF179 Metabolite的純度,GNF179 Metabolite的作用,GNF179 Metabolite抑制劑,GNF179 Metabolite的合成,GNF179 Metabolite的MSDS,GNF179 Metabolite的廠家,GNF179 Metabolite的價格

產(chǎn)品說明	GNF179 Metabolite(1310455-86-7)是GNF179的代謝物,GNF179 Metabolite具有良好的體外代謝穩(wěn)定性和體內(nèi)口服生物相容性。
Introduction	GNF179 Metabolite (1310455-86-7) is a metabolite of GNF179. GNF179 Metabolite has good metabolic stability in vitro and oral biocompatibility in vivo.
Application1
Application2
Application3

警示圖
危險性	warning
危險性警示	Not available
安全聲明	H303吞入可能有害+H313皮膚接觸可能有害+H2413吸入可能對身體有害
安全防護	P264處理后徹底清洗+P280戴防護手套/穿防護服/戴防護眼罩/戴防護面具+P305如果進入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P2393獲得醫(yī)療建議/護理
備注	實驗過程中防止吸入、食入，做好安全防護

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.

Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.

The Molting Biomarker Metabolite N-acetylglucosamino-1,5-lactone in Female Urine of the Helmet Crab Telmessus cheiragonus.

Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.
Perna AF1, Di Nunzio A2, Amoresano A3, Pane F3, Fontanarosa C3, Piero P3, Vigorito C4, Cirillo G2, Zacchia M2, Trepiccione F2, Ingrosso D4. Biochimie. 2016 Apr 26. pii: S0300-9084(16)30071-2. doi: 10.1016/j.biochi.2016.04.018. [Epub ahead of print]
Abstract:Dialysis patients display a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity. Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine β-synthase and cystathionine γ-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production. Hydrogen sulfide is involved in the modulation of multiple pathophysiological responses. In uremia, we have demonstrated low plasma total hydrogen sulfide levels, due to reduced cystathionine γ-lyase expression. Plasma hydrogen sulfide levels were measured in hemodialysis patients and healthy controls with three different techniques in comparison, allowing to discern the different pools of this gas. The protein-bound (the one thought to be the most active) and acid-labile forms are significantly decreased, while homolanthionine, but especially lanthionine, accumulate in the blood of uremic patients.

Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.
Tian X1, Gao Y1, Xu Z2, Lian S3, Ma Y3, Guo X1, Hu P1, Li Z1, Huang C1. Biofactors. 2016 Apr 30. doi: 10.1002/biof.1291. [Epub ahead of print]
Abstract:Mangiferin (MGF), a glucoside of xanthone existing in phytomedicines and food, is increasingly attracting attention on diabetes treatment, while the underlying mechanism leading to its low oral bioavailability is unclear. Norathyriol (NTR), an active metabolite with hypoglycemic activity and its exposure after MGF dosing remains unclear. Hence, a rapid and sensitive LC-MS/MS method was established and validated to determine MGF and NTR and applied in the PK study in rats. Correspondingly, the in vitro experiments on temperature-dependent uptake, and MGF metabolism in hepatocyte and enterobacteria samples were performed. Results revealed that hepatic first-pass effect slightly contributed to the poor bioavailability of MGF, based on the MGF exposure in portal vein plasma was nearly similar to that in systemic plasma, and the MGF accumulation in the liver was limited, so was that of NTR. Correspondingly, the in vitro study revealed the MGF uptake was mainly dependent on poor passive transport, possibly leading to its limited hepatic metabolism and accumulation.

The Molting Biomarker Metabolite N-acetylglucosamino-1,5-lactone in Female Urine of the Helmet Crab Telmessus cheiragonus.
Yano H1, Kamio M2, Nagai H1. Biol Bull. 2016 Apr;230(2):143-151.
Abstract:N-acetylglucosamino-1,5-lactone (NAGL) is a molting biomarker in the blue crab Callinectes sapidus The concentration of this compound in urine is highest at the premolt stage. Since sexually mature premolt females release sex pheromone in their urine, NAGL is a candidate sex pheromone molecule in C. sapidus This compound has not been reported in other species. In the present study, we quantified the concentration of NAGL in the urine of the helmet crab Telmessus cheiragonus, using nuclear magnetic resonance spectroscopy, and found that the concentration increases toward the day of molting and decreases after molting. However, the total amount of NAGL collected from individual animals was greatest two to five days after molting, because the amount of urine collected was the lowest at the premolt stage, and it increased after molting. The highest median concentration of NAGL in T. cheiragonas was 29 μmol l-1, which is 75% of the highest concentration reported in C.

對不起，暫無產(chǎn)品評價！

MSDS

SDS 1.0 中文

展開

SDS 1.0 英文

展開