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Ro3280

NMR下載 COA and HPLC MSDS下載
names：
Ro3280, Polo-like Kinase (PLK) 抑制劑
CAS號：
1062243-51-9
MDL Number：
MF(分子式)： C27H35F2N7O3 MW(分子量)： 543.61
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

RO3280（PLK1 抑制劑，1062243-51-9 ）也稱為 Ro5203280，是一種有效的選擇性 PLK 1 抑制劑，具有出色的體外細(xì)胞效力。Ro3280 (1062243-51-9)is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).

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中文別名	RO3280; RO-3280; RO 3280; Ro5203280; Ro-5203280; Ro 5203280；PLK1抑制劑；PLK1 抑制劑
英文別名	Ro3280；PLK1 inhibitor
CAS號	1062243-51-9
Inchi	InChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33)
InchiKey	DJNZZLZKAXGMMC-UHFFFAOYSA-N
分子式 Formula	C27H35F2N7O3
分子量 Molecular Weight	543.61
溶解度Solubility
性狀	Solid power
儲藏條件 Storage conditions	0 - 4 C for short term (days to weeks), or -20 C for long term (months).

RO3280（PLK1 抑制劑，1062243-51-9 ）的應(yīng)用：
RO3280, also known as Ro5203280, is a potent and selective PLK 1 inhibitor with excellent in vitro cellular potency. RO3280 showed strong antitumor activity in xenograft mouse models. he 50% inhibitory concentration (IC50) of RO3280 for acute leukemia cells was between 74 and 797 nM. The IC50 of RO3280 in primary acute lymphocytic leukemia (ALL) and AML cells was between 35.49 and 110.76 nM and 52.80 and 147.50 nM, respectively. RO3280 induced apoptosis and cell cycle disorder in leukemia cells. RO3280 treatment regulated several apoptosis-associated genes. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs.

產(chǎn)品說明	RO3280，1062243-51-9 也稱為 Ro5203280，是一種有效的選擇性 PLK 1 抑制劑，具有出色的體外細(xì)胞效力。
Introduction	RO3280, 1062243-51-9 also known as Ro5203280, is a potent and selective PLK 1 inhibitor with excellent in vitro cellular potency.
Application1
Application2
Application3

警示圖
危險(xiǎn)性
危險(xiǎn)性警示
安全聲明	H302 H410
安全防護(hù)	P264 P270 P273 P301+P312 P330 P391 P501
備注

HS Tariff Code: 2934.99.9001

1. Chen, S., Bartkovitz, D., Cai, J., et al. Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg. Med. Chem. Lett. 22(2), 1247-1250 (2012).

2. Tao, Y.-F., Li, Z.-H., Du, W.-W., et al. Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation. Oncol. Rep. 37(3), 1419-1429

3. Chen S, et al. Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50.

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