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Theophylline hydrate

NMR下載 COA and HPLC MSDS下載
names：
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrate
CAS號(hào)：
5967-84-0
MDL Number：
MF(分子式)： C7H10N4O3 MW(分子量)： 198.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrate
英文別名	Theophylline; Theoclear-200; Theo-24; T-Phyl; Aerolate JR;
CAS號(hào)	5967-84-0
Inchi	InChI=1S/C7H8N4O2.H2O/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;/h3H,1-2H3,(H,8,9);1H2
InchiKey	INQSMEFCAIHTJG-UHFFFAOYSA-N
分子式 Formula	C7H10N4O3
分子量 Molecular Weight	198.18
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Theophylline hydrate(CAS:5967-84-0 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. doi: 10.1164/rccm.201302-0388PP. Review. PubMed PMID: 23672674.

[2]Pacifici GM. Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics. Curr Pediatr Rev. 2014;10(4):297-303. Review. PubMed PMID: 25594527.

[3] Fernández-Campos F, Ferrero C, Colom H, Jiménez-Castellanos MR. Invivo absorption behaviour of theophylline from starch-methyl methacrylate matrix tablets in beagle dogs. Int J Pharm. 2015 Jan 30;478(2):684-92. doi: 10.1016/j.ijpharm.2014.11.071. Epub 2014 Dec 2. PubMed PMID: 25476254.

[4] DuBois B, Louey S, Giraud GD, Cherala G, Jonker SS. Theophylline Pharmacokinetics in Foetal Sheep: Maternal Metabolic Capacity is the Principal Driver. Basic Clin Pharmacol Toxicol. 2015 Oct;117(4):226-33. doi: 10.1111/bcpt.12395. Epub 2015 Mar 19. PubMed PMID: 25728792; PubMed Central PMCID: PMC4750914.

[5] Voynikov Y, Valcheva V, Momekov G, Peikov P, Stavrakov G. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3043-5. doi: 10.1016/j.bmcl.2014.05.026. Epub 2014 May 17. PubMed PMID: 24878196.

6: Chae JW, An JH, Kang W, Ma Jy, Kwon KI. Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. Food Chem Toxicol. 2012 Oct;50(10):3666-72. doi: 10.1016/j.fct.2012.06.049. Epub 2012 Jul 4. PubMed PMID: 22771369.7: Aswini KK, Vinu Mohan AM, Biju VM. Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;6

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