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Tariquidar dimesylate

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names：
N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide dimesylate
CAS號：
625375-84-0
MDL Number：
MF(分子式)： C40H46N4O12S2 MW(分子量)： 838.94
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide dimesylate
英文別名	Tariquidar dimesylate; Tariquidar dimesilate; XR 9576, XR9576, XR-9576, D06008, D 06008, D-06008,
CAS號	625375-84-0
Inchi	InChI=1S/C38H38N4O6.2CH4O3S/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27;21-5(2,3)4/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43);21H3,(H,2,3,4)
InchiKey	FBCFBFPCZHHRMA-UHFFFAOYSA-N
分子式 Formula	C40H46N4O12S2
分子量 Molecular Weight	838.94
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Tariquidar dimesylate(CAS:625375-84-0 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Tariquidar, also known as XR9576, is a P-glycoprotein (P-gp) inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Joshi P, Vishwakarma RA, Bharate SB. Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer. Eur J Med Chem. 2017 Sep 29;138:273-292. doi: 10.1016/j.ejmech.2017.06.047. Epub 2017 Jun 27. Review. PubMed PMID: 28675836.

[2]Lubberink M. Kinetic Models for Measuring P-glycoprotein Function at the Blood-Brain Barrier with Positron Emission Tomography. Curr Pharm Des. 2016;22(38):5786-5792. Review. PubMed PMID: 27494063.

[3] Zinzi L, Capparelli E, Cantore M, Contino M, Leopoldo M, Colabufo NA. Small and Innovative Molecules as New Strategy to Revert MDR. Front Oncol. 2014 Jan 21;

[4]2. doi: 10.3389/fonc.2014.00002. eCollection 2014. Review. PubMed PMID: 24478983; PubMed Central PMCID: PMC3896858.

[5] Wanek T, Mairinger S, Langer O. Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier. J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):68-77. doi: 10.1002/jlcr.2993. Review. PubMed PMID: 24285312.

5: Lecerf-Schmidt F, Peres B, Valdameri G, Gauthier C, Winter E, Payen L, Di Pietro A, Boumendjel A. ABCG

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