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SB-220025 trihydrochloride

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names：
5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
CAS號：
197446-75-6
MDL Number：
MF(分子式)： C18H22Cl3FN6 MW(分子量)： 447.7644
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
英文別名	SB 220025 ; SB220025; SB-220025 trihydrochloride
CAS號	197446-75-6
Inchi	InChI=1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H
InchiKey	IPFBHUGKKONHFR-UHFFFAOYSA-N
分子式 Formula	C18H22Cl3FN6
分子量 Molecular Weight	447.7644
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	SB-220025 trihydrochloride(CAS:197446-75-6 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	SB-220025 trihydrochloride is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
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備注

[1]Bell CE, Watson AJ. p38 MAPK regulates cavitation and tight junction function in the mouse blastocyst. PLoS One. 2013 Apr 4;8(4):e59528. doi: 10.1371/journal.pone.0059528. Print 2013. PubMed PMID: 23593143; PubMed Central PMCID: PMC3617173.

[2]Kanaji N, Nelson A, Allen-Gipson DS, Sato T, Nakanishi M, Wang X, Li Y, Basma H, Michalski J, Farid M, Rennard SI, Liu X. The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflamm Res. 2012 Mar;61(3):233-44. doi: 10.1007/s00011-011-0405-7. Epub 2011 Dec 3. PubMed PMID: 22138711.

[3] Campbell JS, Argast GM, Yuen SY, Hayes B, Fausto N. Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol. 2011 Feb;43(2):180-8. doi: 10.1016/j.biocel.2010.08.002. Epub 2010 Aug 11. PubMed PMID: 20708092; PubMed Central PMCID: PMC3022113.

[4] Sharma A, Guan H, Yang K. The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. Endocrinology. 2009 Sep;150(9):4278-86. doi: 10.1210/en.2009-0479. Epub 2009 Jun 4. PubMed PMID: 19497972.

[5] Watanabe J, Natsume T, Kobayashi M. The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity. Anticancer Res. 2007 Nov-Dec;27(6B):3909-18. PubMed PMID: 18225550.

6: Ishii T, Sootome H, Toyoda H, Suda M, Noumi T, Yamashita K. Dual enzyme-linked immunosorbent assay system for detection of endogenous kinase activities of mitogen- and stress-activated protein kinase-1/2. Assay Drug Dev Technol. 2007 Aug;5(4):523-33. PubMed PMID: 17767420.7: Winger QA, Guttormsen J, Gavin H, Bhushan F. Heat shock protein 1 and the mitogen-activated protein kinase 14 pathway are important for mouse trophoblast stem cell differentiation. Biol Reprod. 2007 May;76(5):884-91. Epub 2007 Jan 31. PubMed PMID: 17267699.8: Lahti A, Sareila O, Kankaanranta H, Moilanen E. Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression. BMC Pharmacol. 2006 Feb 21;

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