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RU28318 potassium

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names：
potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate
CAS號(hào)：
76676-34-1
MDL Number：
MF(分子式)： C25H37KO4 MW(分子量)： 440.66
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	potassium 3-((7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-3-oxo-7-propyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)propanoate
英文別名	RU28318; RU 28318; RU-28318; RU 28318, potassium salt.
CAS號(hào)	76676-34-1
Inchi	InChI=1S/C25H38O4.K/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24,29)13-9-21(27)28;/h15-16,19-20,22,29H,4-14H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,19+,20+,22-,23+,24+,25+;/m1./s1
InchiKey	HXJITUGMCJCKCE-NKTBGYRQSA-M
分子式 Formula	C25H37KO4
分子量 Molecular Weight	440.66
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	RU28318 potassium(CAS:76676-34-1 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	RU 28318, potassium salt is a potent and selective antagonist for the mineralocorticoid receptor (MR). RU 28318, potassium salt inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. It also decreases blood pressure in female rats following central administration in vivo.
Application1
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危險(xiǎn)性	Warning
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[1]Benter IF, Babiker F, Al-Rashdan I, Yousif M, Akhtar S. RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes. J Diabetes Res. 2013;201

3:427693. doi: 10.1155/2013/427693. Epub 2013 Aug 27. PubMed PMID: 24066305; PubMed Central PMCID: PMC3771425.

[3]Kim PJ, Cole MA, Kalman BA, Spencer RL. Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J Steroid Biochem Mol Biol. 1998 Nov;67(3):213-22. PubMed PMID: 9879980.

[4]Souness GW, Morris DJ. The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type I) antagonist RU28318. Endocrinology. 1991 Nov;129(5):2451-6. PubMed PMID: 1657575.

[5] Gómez-Sánchez EP, Fort CM, Gómez-Sánchez CE. Intracerebroventricular infusion of RU28318 blocks aldosterone-salt hypertension. Am J Physiol. 1990 Mar;258(3 Pt 1):E482-4. PubMed PMID: 2316642.

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