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Leteprinim potassium

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names：
potassium 4-(3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanamido)benzoate
CAS號(hào)：
192564-13-9
MDL Number：
MF(分子式)： C15H12KN5O4 MW(分子量)： 365.3903
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Leteprinim potassium
英文別名	AIT-082; SPI-205; AIT082; SPI205; AIT 082; SPI 205
CAS號(hào)	192564-13-9
Inchi	InChI=1S/C15H13N5O4.K/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22;/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22);/q;+1/p-1
InchiKey	MICLTPPSCUXHJT-UHFFFAOYSA-M
分子式 Formula	C15H12KN5O4
分子量 Molecular Weight	365.3903
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Leteprinim potassium(CAS:192564-13-9 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Leteprinim, also known as AIT-082 and SPI-205, is a neurotrophic agent potentially for the treatment of Alzheimer's disease, and spinal cord injury.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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備注

[1]Morrone CD, Thomason LA, Brown ME, Aubert I, McLaurin J. Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease. PLoS One. 2016 Oct 21;11(10):e0165393. doi: 10.1371/journal.pone.0165393. PubMed PMID: 27768761; PubMed Central PMCID: PMC5074589.

[2]Jiang S, Khan MI, Middlemiss PJ, Lu Y, Werstiuk ES, Crocker CE, Ciccarelli R, Caciagli F, Rathbone MP. AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats. Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):353-66. PubMed PMID: 15461869.

[3] Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. Review. PubMed PMID: 15298067.

[4] Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. PubMed PMID: 12949633.

[5] Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 Dec;24(10):703-29. PubMed PMID: 12616965.

6: Yan R, Taylor EM. Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters. Drug Metab Dispos. 2002 May;30(5):513-8. PubMed PMID: 11950780.7: Rathbone MP, Middlemiss PJ, Crocker CE, Glasky MS, Juurlink BH, Ramirez JJ, Ciccarelli R, Di Iorio P, Caciagli F. AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opin Investig Drugs. 1999 Aug;8(8):1255-62. PubMed PMID: 15992149.

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