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HA-1004 HCl

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names：
N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide Dihydrochloride
CAS號：
92564-08-4
MDL Number：
MF(分子式)： C12H17Cl2N5O2S MW(分子量)： 366.261
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	HA-1004 HCl
英文別名	HA-1004; HA 1004; HA1004; HA-1004 HCl; HA-1004 dihydrochloride;
CAS號	92564-08-4
Inchi	InChI=1S/C12H15N5O2S.2ClH/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11;;/h1-5,8,17H,6-7H2,(H4,13,14,16);2*1H
InchiKey	PMTUBVLLVFJRLK-UHFFFAOYSA-N
分子式 Formula	C12H17Cl2N5O2S
分子量 Molecular Weight	366.261
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	HA-1004 HCl(CAS:92564-08-4 ):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	HA-1004 is an inhibitor of PKA, cGKI, PKC, MYLK, and calcium channel protein.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Almela P, García-Carmona JA, Martínez-Laorden E, Milanés MV, Laorden ML. Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal. Front Pharmacol. 2013 Dec 27;

4:164. doi: 10.3389/fphar.2013.00164. eCollection 2013. PubMed PMID: 24409147; PubMed Central PMCID: PMC3873507.

[3]Villarruel EQ, Borda E, Sterin-Borda L, Orman B. Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity. Cell Biol Int. 2011 Aug;35(8):783-8. doi: 10.1042/CBI20100200. PubMed PMID: 21047305.

[4]Almela P, Atucha NM, Milanés MV, Laorden ML. Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. J Pharmacol Exp Ther. 2009 Sep;330(3):771-82. doi: 10.1124/jpet.109.154583. Epub 2009 Jun 30. PubMed PMID: 19567779.

[5] Varga F, Rumpler M, Spitzer S, Karlic H, Klaushofer K. Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts. Endocr J. 2009;56(3):441-50. Epub 2009 Feb 18. PubMed PMID: 19225217.

5: Almela P, Victoria Milanés M, Luisa Laorden M. Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle. Basic Res Cardiol. 2009 Jul;104(4):366-76. doi: 10.1007/s00395-008-0768-2. Epub 2008 Dec 22. PubMed PMID: 19104749.

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