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DB772

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names：
2-(5-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)furan-2-yl)-1H-benzo[d]imidazole
CAS號：
1451058-50-6
MDL Number：
MF(分子式)： C20H16N4O MW(分子量)： 328.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	DB772
英文別名	DB772; DB-772; DB 772;
CAS號	1451058-50-6
Inchi	InChI=1S/C20H16N4O/c1-2-4-16-15(3-1)23-20(24-16)18-10-9-17(25-18)13-5-7-14(8-6-13)19-21-11-12-22-19/h1-10H,11-12H2,(H,21,22)(H,23,24)
InchiKey	XDFQDDCYYZDDDY-UHFFFAOYSA-N
分子式 Formula	C20H16N4O
分子量 Molecular Weight	328.37
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	DB772(CAS:1451058-50-6 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	DB772 is a monocationic inhibitor of scrapie prion accumulation.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Dinkel KD, Stanton JB, Boykin DW, Stephens CE, Madsen-Bouterse SA, Schneider DA. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. doi: 10.1128/AAC.00811-16. Print 2016 Sep. PubMed PMID: 27381401; PubMed Central PMCID: PMC4997874.

[2]Newcomer BW, Marley MS, Galik PK, Zhang Y, Riddell KP, Boykin DW, Kumar A, Kuhnt LA, Gard JA, Givens MD. Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus. Can J Vet Res. 2013 Jul;77(3):170-6. PubMed PMID: 24101792; PubMed Central PMCID: PMC3700441.

[3] Newcomer BW, Neill JD, Marley MS, Ridpath JF, Givens MD. Mutations induced in the NS5B gene of bovine viral diarrhea virus by antiviral treatment convey resistance to the compound. Virus Res. 2013 Jun;174(1-2):95-100. doi: 10.1016/j.virusres.2013.03.007. Epub 2013 Mar 21. PubMed PMID: 23524138.

[4] Stanton JB, Schneider DA, Dinkel KD, Balmer BF, Baszler TV, Mathison BA, Boykin DW, Kumar A. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. doi: 10.1371/journal.pone.0051173. Epub 2012 Nov 30. Erratum in: PLoS One. 2015;10(3):e0119084. PubMed PMID: 23226483; PubMed Central PMCID: PMC3511409.

[5] Newcomer BW, Marley MS, Ridpath JF, Neill JD, Boykin DW, Kumar A, Givens MD. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. doi: 10.1016/j.antiviral.2012.09.005. Epub 2012 Sep 14. PubMed PMID: 22985628.

6: Newcomer BW, Marley MS, Galik PK, Walz PH, Zhang Y, Riddell KP, Dykstra CC, Boykin DW, Kumar A, Cruz-Espindola C, Boothe DM, Joiner KS, Givens MD. Antiviral treatment of calves persistently infected with bovine viral diarrhoea virus. Antivir Chem Chemother. 2012 Jan 17;22(4):171-9. doi: 10.3851/IMP1903. PubMed PMID: 22182713.7: Givens MD, Stringfellow DA, Dykstra CC, Riddell KP, Galik PK, Sullivan E, Robl J, Kasinathan P, Kumar A, Boykin DW. Prevention and elimination of bovine viral diarrhea virus infections in fetal fibroblast cells. Antiviral Res. 2004 Nov;64(2):113-8. PubMed PMID: 15498606.

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