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Bifeprunox Mesylate

NMR下載 COA and HPLC MSDS下載
names：
7-(4-(Biphenyl-3-ylmethyl)piperazin-1-yl)benzoxazol-2(3H)-one methanesulfonate
CAS號(hào)：
350992-13-1
MDL Number：
MF(分子式)： C25H27N3O5S MW(分子量)： 481.567
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Bifeprunox Mesylate
英文別名	Bifeprunox; Bifeprunox Mesylate; DU-127090; DU 127090; DU127090.
CAS號(hào)	350992-13-1
Inchi	InChI=1S/C24H23N3O2.CH4O3S/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19;1-5(2,3)4/h1-11,16H,12-15,17H2,(H,25,28);1H3,(H,2,3,4)
InchiKey	ONWKHSGOYGLGPO-UHFFFAOYSA-N
分子式 Formula	C25H27N3O5S
分子量 Molecular Weight	481.567
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Bifeprunox Mesylate(CAS:350992-13-1 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Bifeprunox, also known as DU-127090, is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox influences nicotine-seeking behaviour in response to drug-associated stimuli in rats. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation.
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[1]Chattopadhyay A, Frey S, Green G, Harkness A, McDermott A, Yates A. Bifeprunox vs Placebo for Schizophrenia. Schizophr Bull. 2016 Jul;42(4):881-2. doi: 10.1093/schbul/sbw048. Epub 2016 May 6. PubMed PMID: 27153863; PubMed Central PMCID: PMC4903068.

[2]De Santis M, Pan B, Lian J, Huang XF, Deng C. Different effects of bifeprunox, aripiprazole, and haloperidol on body weight gain, food and water intake, and locomotor activity in rats. Pharmacol Biochem Behav. 2014 Sep;12

4:167-73. doi: 10.1016/j.pbb.2014.06.004. Epub 2014 Jun 13. PubMed PMID: 24933333.

[4]Di Clemente A, Franchi C, Orrù A, Arnt J, Cervo L. Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats. Addict Biol. 2012 Mar;17(2):274-86. doi: 10.1111/j.1369-1600.2011.00319.x. Epub 2011 Apr 26. PubMed PMID: 21521422.

[5] Spiros A, Carr R, Geerts H. Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse. Neuropsychiatr Dis Treat. 2010 Sep 7;

6:589-603. doi: 10.2147/NDT.S12460. PubMed PMID: 20856922; PubMed Central PMCID: PMC2938308.

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