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Aprikalim (racemic)

NMR下載 COA and HPLC MSDS下載
names：
2H-Thiopyran-2-carbothioamide, tetrahydro-N-methyl-2-(3-pyridinyl)-, 1-oxide, trans
CAS號(hào)：
89544-10-5
MDL Number：
MF(分子式)： C12H16N2OS2 MW(分子量)： 268.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Aprikalim (racemic)
英文別名	RP 49356; RP-49356; RP49356; Aprikalim; RP 52891; RP-52891; RP-52891;
CAS號(hào)	89544-10-5
Inchi	InChI=1S/C12H16N2OS2/c1-13-11(16)12(6-2-3-8-17(12)15)10-5-4-7-14-9-10/h4-5,7,9H,2-3,6,8H2,1H3,(H,13,16)/t12-,17-/m0/s1
InchiKey	GKEMHVLBZNVZOI-SJCJKPOMSA-N
分子式 Formula	C12H16N2OS2
分子量 Molecular Weight	268.39
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Aprikalim (racemic)(CAS:89544-10-5 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	RP-49356 is a potassium adenosine triphosphate (ATP) channel opener which may reduce neurologic injury. Aprikalim may also offer protection of heart tissue from free radicals.
Application1
Application2
Application3

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危險(xiǎn)性	Warning
危險(xiǎn)性警示
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[1]Lozos VA, Toumpoulis IK, Agrogiannis G, Giamarellos-Bourboulis EJ, Chamogeorgakis TP, Rizos IK, Patsouris ES, Anagnostopoulos CE, Rokkas CK. Aprikalim a potassium adenosine triphosphate channel opener reduces neurologic injury in a rabbit model of spinal cord ischemia. Int J Surg. 2013;11(4):354-9. doi: 10.1016/j.ijsu.2013.02.025. Epub 2013 Mar 5. PubMed PMID: 23473993.

[2]Belin V, Hodge T, Picaut P, Jordan R, Algate C, Gosselin S, Nohynek G, Cavero I. The myocardial lesions produced by the potassium channel opener aprikalim in monkeys and rats are prevented by blockade of cardiac beta-adrenoceptors. Fundam Appl Toxicol. 1996 Jun;31(2):259-67. PubMed PMID: 8789792.

[3] Pignac J, Lacaille C, Dumont L. Protective effects of the K+ ATP channel opener, aprikalim, against free radicals in isolated rabbit hearts. Free Radic Biol Med. 1996;20(3):383-9. PubMed PMID: 8720909.

[4] Chevalier P, Rouillard C, Montay G, Frydman A. Aprikalim: radioimmunoassay and pharmacokinetic studies in mouse, monkey, and dog. J Pharm Sci. 1994 Mar;83(3):372-8. PubMed PMID: 8207684.

[5] Pignac J, Bourgouin J, Dumont L. Cold cardioplegia and the K+ channel modulator aprikalim (RP 52891): improved cardioprotection in isolated ischemic rabbit hearts. Can J Physiol Pharmacol. 1994 Feb;72(2):126-32. PubMed PMID: 8050052.

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