購(gòu)物車 
-
Alvameline Tartrate
- names：
5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine (2R,3R)-2,3-dihydroxysuccinate
- CAS號(hào)：
159792-14-0
MDL Number： - MF(分子式)： C13H21N5O6 MW(分子量)： 343.34
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
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| 中文別名 | Alvameline Tartrate |
| 英文別名 | LU-25-109T; LU-25109T; LU 25 109T; LU 25109T |
| CAS號(hào) | 159792-14-0 |
| Inchi | InChI=1S/C9H15N5.C4H6O6/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8;5-1(3(7)8)2(6)4(9)10/h5H,3-4,6-7H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1 |
| InchiKey | JHGFYOXAUPXDGA-LREBCSMRSA-N |
| 分子式 Formula | C13H21N5O6 |
| 分子量 Molecular Weight | 343.34 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Alvameline Tartrate(CAS:159792-14-0 ):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Alvameline Tartrate is a muscarinic M1 receptor agonist and M2/M3 receptor antagonist potentially for treatment of urinary incontinence. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Waldeck K, Larsson B, Sandberg B, Andersson K-. Actions of the new antimuscarinic compound Lu 25-109 on isolated human and pig detrusor. Neurourol Urodyn. 2002;21(1):92-8. PubMed PMID: 11835429. |
| [2]Sveigaard HH, Dalgaard L. Evaluation of blood-brain barrier passage of a muscarine M1 agonist and a series of analogous tetrahydropyridines measured by in vivo microdialysis. Pharm Res. 2000 Jan;17(1):70-6. PubMed PMID: 10714611. |
| [3] Forlenza OV, Spink JM, Dayanandan R, Anderton BH, Olesen OF, Lovestone S. Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons. J Neural Transm (Vienna). 2000;107(10):1201-12. PubMed PMID: 11129110. |
| [4] Thal LJ, Forrest M, Loft H, Mengel H. Lu 25-109, a muscarinic agonist, fails to improve cognition in Alzheimer's disease. Lu25-109 Study Group. Neurology. 2000 Jan 25;54(2):421-6. PubMed PMID: 10668706. |
| [5] Christensen EB, Andersen JB, Pedersen H, Jensen KG, Dalgaard L. Metabolites of [(14)C]-5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3, 6-tetrahydropyridine in mice, rats, dogs, and humans. Drug Metab Dispos. 1999 Nov;27(11):1341-9. PubMed PMID: 10534320. |
6: Jensen KG, Dalgaard L. In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7.4 and 8.5. Drug Metab Dispos. 1999 Jan;27(1):125-32. PubMed PMID: 9884321.7: Sánchez C, Arnt J, Didriksen M, Dragsted N, Moltzen Lenz S, Matz J. In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40. PubMed PMID: 9683000.8: Bymaster FP, Carter PA, Peters SC, Zhang W, Ward JS, Mitch CH, Calligaro DO, Whitesitt CA, DeLapp N, Shannon HE, Rimvall K, Jeppesen L, Sheardown MJ, Fink-Jensen A, Sauerberg P. Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. Brain Res. 1998 Jun 8;795(1-2):179-90. PubMed PMID: 9622623.9: Müller D, Wiegmann H, Langer U, Moltzen-Lenz S, Nitsch RM. Lu 25-109, a combined m1 agonist and m2 antagonist, modulates regulated processing of the amyloid precursor protein of Alzheimer's disease. J Neural Transm (Vienna). 1998;105(8-9):1029-43. PubMed PMID: 9869334.10: Sramek JJ, Forrest M, Mengel H, Jhee SS, Hourani J, Cutler NR. A bridging study of LU 25-109 in patients with probable Alzheimer's disease. Life Sci. 1998;62(3):195-202. PubMed PMID: 9488097.1
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