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草苔蟲(chóng)素 1

NMR下載 COA and HPLC MSDS下載
names：
Bryostatin 1
CAS號(hào)：
83314-01-6
MDL Number： MFCD00893832
MF(分子式)： C47H68O17 MW(分子量)： C47H68O17
EINECS: Reaxys Number:
Pubchem ID:5280757 Brand:BIOFOUNT

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中文別名	草苔蟲(chóng)素 -1；草苔蟲(chóng)素雜質(zhì)；草苔蟲(chóng)素 A;
英文別名	Bryostatin 1； UNII-37O2X55Y9E； 83314-01-6； NSC 339555； CHEMBL449158； Bryostatin-1； CHEBI:88353； 7O2X55Y9E； BRYOSTATIN； BRN 4349157；[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate;EH9455000
CAS號(hào)	83314-01-6
Inchi	InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
InchiKey	MJQUEDHRCUIRLF-TVIXENOKSA-N
分子式 Formula	C47H68O17
分子量 Molecular Weight	C47H68O17
溶解度Solubility
性狀	white;solid; power
儲(chǔ)藏條件 Storage conditions	Store at -4℃； -20℃存儲(chǔ)更長(zhǎng)時(shí)間（2-3年）

產(chǎn)品說(shuō)明	Bryostatin 1是從具有抗腫瘤活性的苔蘚蟲(chóng)（Bugula neritina）分離的大環(huán)內(nèi)酯。 Bryostatin 1結(jié)合并抑制細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)酶蛋白激酶C，從而抑制腫瘤細(xì)胞增殖，促進(jìn)腫瘤細(xì)胞分化和誘導(dǎo)腫瘤細(xì)胞凋亡，該試劑可以與其他化學(xué)治療劑協(xié)同作用。
Introduction	Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells
Application1	Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects
Application2	Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon
Application3	The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line

Bryostatin 1是從具有抗腫瘤活性的苔蘚蟲(chóng)（Bugula neritina）分離的大環(huán)內(nèi)酯。 Bryostatin 1結(jié)合并抑制細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)酶蛋白激酶C，從而抑制腫瘤細(xì)胞增殖，促進(jìn)腫瘤細(xì)胞分化和誘導(dǎo)腫瘤細(xì)胞凋亡。該試劑可以與其他化學(xué)治療劑協(xié)同作用。

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

警示圖
危險(xiǎn)性
危險(xiǎn)性警示	Mouse(iv): LD50: 0.075 mg/kg;Rat(iv): LD50: 0.068 mg/kg
安全聲明	H303+H313+H333
安全防護(hù)	P264+P280+P305+P351+P338+P337+P313
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