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ZM 241385

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names：
ZM 241385, A2A antagonist
CAS號(hào)：
139180-30-6
MDL Number：
MF(分子式)： C16H15N7O2 MW(分子量)： 337.34
EINECS: Reaxys Number:
Pubchem ID:176407 Brand:BIOFOUNT

ZM 241385, A2A antagonist(139180-30-6)是 A2A 腺苷受體的強(qiáng)效拮抗劑（pIC50 = 9.52，用于置換大鼠嗜鉻細(xì)胞瘤細(xì)胞膜上的 5'-N-乙基甲酰胺基腺苷）。ZM 241385 對其他 A 腺苷受體幾乎沒有活性或沒有活性，它作為人 A2B 腺苷受體的組成型活性突變體的反向激動(dòng)劑

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中文別名	ZM 241385(139180-30-6);4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol;A2A拮抗劑
英文別名	ZM 241385, A2A antagonist(139180-30-6);ZM-241385;ZM 241385.
CAS號(hào)	139180-30-6
Inchi	InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
InchiKey	PWTBZOIUWZOPFT-UHFFFAOYSA-N
分子式 Formula	C16H15N7O2
分子量 Molecular Weight	337.34
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	ZM 241385, A2A antagonist(139180-30-6)是 A2A 腺苷受體的強(qiáng)效拮抗劑（pIC50 = 9.52，用于置換大鼠嗜鉻細(xì)胞瘤細(xì)胞膜上的 5'-N-乙基甲酰胺基腺苷）。
Introduction	ZM241385 is an adenosine A2A-receptor antagonist. ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. ZM241385 is a useful tool to study A2A-receptor function.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示	P264處理后徹底清洗+P280戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具+P305如果進(jìn)入眼睛+P351用水小心沖洗幾分鐘+P338取出隱形眼鏡（如果有）并且易于操作,繼續(xù)沖洗+P337如果眼睛刺激持續(xù)+P313獲得醫(yī)療建議/護(hù)理
安全聲明	H315 H319 H335
安全防護(hù)	P264 P302+P352 P304+P340 P305+P351+P338 P332+P313 P337+P313
備注

[1]Guo D, Xia L, van Veldhoven JP, Hazeu M, Mocking T, Brussee J, Ijzerman AP, Heitman LH. Binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor. ChemMedChem. 2014 Apr;9(4):752-6[1]doi: 10.1002/cmdc.201300474. Epub 2014 Mar 3. PubMed PMID: 24591302.

[2]Li X, Kang H, Liu X, Liu Z, Shu K, Chen X, Zhu S. Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):257-64. doi: 10.1007/s11596-012-0046-2. Epub 2012 Apr 20. PubMed PMID: 22528231.

[3] Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH. Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Structure. 2011 Sep 7;19(9):1283-93. doi: 10.1016/j.str.2011.06.014. PubMed PMID: 21885291; PubMed Central PMCID: PMC3732996.

[4] Wang Z, Che PL, Du J, Ha B, Yarema KJ. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. PLoS One. 2010 Nov 8;5(11):e13883. doi: 10.1371/journal.pone.0013883. PubMed PMID: 21079735; PubMed Central PMCID: PMC2975637.

[5] Pugliese AM, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini MG, Galli A, Pedata F. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 2009 Jul;157(5):818-30. doi: 10.1111/j.1476-5381.2009.00218.x. Epub 2009 May 5. PubMed PMID: 19422385; PubMed Central PMCID: PMC2721266.

6: Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J Pharmacol Exp Ther. 2007 Feb;320(2):637-45. Epub 2006 Oct 31. PubMed PMID: 17077318.7: Uustare A, Vonk A, Terasmaa A, Fuxe K, Rinken A. Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors. Life Sci. 2005 Feb 11;76(13):1513-26. Epub 2004 Dec 19. Erratum in: Life Sci. 2005 Jun 3;77(3):359. PubMed PMID: 15680315.8: Alexander SP, Millns PJ. [(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain. Eur J Pharmacol. 2001 Jan 12;411(3):205-10. PubMed PMID: 11164377.9: Arif Hasan AZ, Abebe W, Mustafa SJ. Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385. J Cardiovasc Pharmacol. 2000 Feb;35(2):322-5. PubMed PMID: 10672868.10: Cunha RA, Constantino MD, Ribeiro JA. ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Br J Pharmacol. 1997 Dec;122(7):1279-84. PubMed PMID: 9421273; PubMed Central PMCID: PMC1565069.

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