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Zamifenacin

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names：
(R)-3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine
CAS號：
127308-82-1
MDL Number：
MF(分子式)： C27H29NO3 MW(分子量)： 415.533
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(R)-3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine
英文別名	UK 76654; UK76654; UK-76654; Zamifenacin
CAS號	127308-82-1
Inchi	InChI=1S/C27H29NO3/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2/t24-/m1/s1
InchiKey	BDNFQGRSKSQXRI-XMMPIXPASA-N
分子式 Formula	C27H29NO3
分子量 Molecular Weight	415.533
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Zamifenacin(CAS:127308-82-1):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Zamifenacin, also known as UK-76654, is a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Houghton LA, Rogers J, Whorwell PJ, Campbell FC, Williams NS, Goka J. Zamifenacin (UK-76, 654) a potent gut M3 selective muscarinic antagonist, reduces colonic motor activity in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997 Jun;11(3):561-8. PubMed PMID: 9218083.

[2]Amacher DE, Fasulo LM, Charuel C, Comby P, Beaumont K. In vitro toxicity of zamifenacin (UK-76,654) and metabolites in primary hepatocyte cultures. Xenobiotica. 1998 Sep;28(9):895-908. PubMed PMID: 9764931.

[3] Watson N, Reddy H, Stefanich E, Eglen RM. Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur J Pharmacol. 1995 Oct 16;285(2):135-42. PubMed PMID: 8566131.

[4] Beaumont KC, Causey AG, Coates PE, Smith DA. Pharmacokinetics and metabolism of zamifenacin in mouse, rat, dog and man. Xenobiotica. 1996 Apr;26(4):459-71. PubMed PMID: 9173686.

[5] Hughes T, Wright AR, Owen JP, Keir MJ. Computerized planimetry in the objective assessment of the antispasmodic effect of Zamifenacin in double contrast barium enemas. Br J Radiol. 1996 Apr;69(820):301-5. PubMed PMID: 8665128.

6: Barlow RB, Bond SM, Branthwaite AG, Jackson O, McQueen DS, Smith KM, Smith PJ. Selective blockade of M2 and M3 muscarinic receptors by hexahydrobenzyl-fourdapine and a comparison with zamifenacin. Br J Pharmacol. 1995 Dec;116(7):2897-902. PubMed PMID: 8680722; PubMed Central PMCID: PMC1909210.7: Golding JF, Stott JR. Comparison of the effects of a selective muscarinic receptor antagonist and hyoscine (scopolamine) on motion sickness, skin conductance and heart rate. Br J Clin Pharmacol. 1997 Jun;43(6):633-7. PubMed PMID: 9205824; PubMed Central PMCID: PMC2042789.8: Wallis RM. Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists. Life Sci. 1995;56(11-12):861-8. PubMed PMID: 10188786.9: Zholos AV, Bolton TB. Muscarinic receptor subtypes controlling the cationic current in guinea-pig ileal smooth muscle. Br J Pharmacol. 1997 Nov;122(5):885-93. PubMed PMID: 9384504; PubMed Central PMCID: PMC1564999.10: Cossy J. Selective methodologies for the synthesis of biologically active piperidinic compounds. Chem Rec. 2005;5(2):70-80. Review. PubMed PMID: 15825169.1

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