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Y 20811

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names：
Benzoic acid, 4-(hydroxy(5-(1H-imidazol-1-yl)-2-methylphenyl)methyl)-3,5-dimethyl-, monosodium salt
CAS號：
104363-98-6
MDL Number：
MF(分子式)： C20H19N2NaO3 MW(分子量)： 358.3728
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Benzoic acid, 4-(hydroxy(5-(1H-imidazol-1-yl)-2-methylphenyl)methyl)-3,5-dimethyl-, monosodium salt
英文別名	Y 20811; Y-20811; Y 20811
CAS號	104363-98-6
Inchi	InChI=1S/C20H20N2O3.Na/c1-12-4-5-16(22-7-6-21-11-22)10-17(12)19(23)18-13(2)8-15(20(24)25)9-14(18)3;/h4-11,19,23H,1-3H3,(H,24,25);/q;+1/p-1/t19-;/m1./s1
InchiKey	HRUWEADDSLYBSH-FSRHSHDFSA-M
分子式 Formula	C20H19N2NaO3
分子量 Molecular Weight	358.3728
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Y 20811(CAS:104363-98-6):僅限應(yīng)用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Y 20811 is a biochemical.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Sakai H, Suzuki T, Murota M, Takahashi Y, Takeguchi N. Nitric oxide-induced Cl- secretion in isolated rat colon is mediated by the release of thromboxane A2. J Physiol. 2002 Aug 15;543(Pt 1):261-7[1]PubMed PMID: 12181297; PubMed Central PMCID: PMC2290489.

[2]Suzuki T, Sakai H, Takeguchi N. Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. Eur J Pharmacol. 2000 Jul 21;400(2-3):297-303. PubMed PMID: 10988347.

[3] Sakai H, Sato T, Hamada N, Yasue M, Ikari A, Kakinoki B, Takeguchi N. Thromboxane A2, released by the anti-tumour drug irinotecan, is a novel stimulator of Cl- secretion in isolated rat colon. J Physiol. 1997 Nov 15;505 ( Pt 1):133-44. PubMed PMID: 9409477; PubMed Central PMCID: PMC1160099.

[4] Sumiyoshi A, Asada Y, Marutsuka K, Hayashi T, Kisanuki A, Tsuneyoshi A, Sato Y. Platelets and intimal thickening. Ann N Y Acad Sci. 1995 Jan 17;748:74-85; discussion 85. Review. PubMed PMID: 7695225.

[5] Matsumoto Y, Noguchi Y, Inui J. [Effect of Y-20811, a thromboxane A2 synthetase inhibitor, on the arachidonic acid-induced response in the blood-superfused canine coronary artery]. Nihon Yakurigaku Zasshi. 1994 Feb;103(2):59-66. Japanese. PubMed PMID: 8112690.

6: Fujimura M, Mikashima H. Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits. Thromb Res. 1993 May 1;70(3):233-44. PubMed PMID: 8327988.7: Sato N, Endo T, Kiuchi K, Hayakawa H. Effects of a thromboxane synthetase inhibitor, Y-20811, on infarct size, neutrophil accumulation, and arrhythmias after coronary artery occlusion and reperfusion in dogs. J Cardiovasc Pharmacol. 1993 Mar;21(3):353-61. PubMed PMID: 7681494.8: Umemura K, Asai Y, Uematsu T, Nakashima M. Role of thromboxane A2 in a microcirculation disorder of the rat inner ear. Eur Arch Otorhinolaryngol. 1993;250(6):342-4. PubMed PMID: 8260145.9: Fukuchi M, Uematsu T, Araki S, Nakashima M. Photochemically induced thrombosis of the rat coronary artery and functional evaluation of thrombus formation by occurrence of ventricular arrhythmias. Effects of acetylsalicylic acid and a thromboxane A2 synthetase inhibitor of thrombus formation. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):550-4. PubMed PMID: 1470226.10: Fujii T, Matsuzaki M, Oda T, Sakai H, Tanaka N, Yano M, Miura T, Kohno M, Katayama K, Kusukawa R. Effect of the combination of anticoagulant and thromboxane synthetase inhibitor (Y-20811) or receptor blockade (S-1452) on preventing thrombotic cyclic coronary flow reduction in dogs with coronary stenosis. Jpn Circ J. 1992 Nov;56(11):1191-7. PubMed PMID: 1453545.1

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