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Viriditoxin

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names：
dimethyl 2,2'-(9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-3,3',4,4'-tetrahydro-1H,1'H-[8,8'-bibenzo[g]isochromene]-3,3'-diyl)diacetate
CAS號：
35483-50-2
MDL Number：
MF(分子式)： C34H30O14 MW(分子量)： 662.6
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	dimethyl 2,2'-(9,9',10,10'-tetrahydroxy-7,7'-dimethoxy-1,1'-dioxo-3,3',4,4'-tetrahydro-1H,1'H-[8,8'-bibenzo[g]isochromene]-3,3'-diyl)diacetate
英文別名	Viriditoxin; SC 28762; SC-28762; SC28762;
CAS號	35483-50-2
Inchi	InChI=1S/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
InchiKey	KPSSJZWNGXQOMD-UHFFFAOYSA-N
分子式 Formula	C34H30O14
分子量 Molecular Weight	662.6
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Viriditoxin(CAS:35483-50-2):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Viriditoxin is a secondary metabolite isolated from Aspergillus viridinutans that has been shown to inhibit FtsZ, the bacterial homologue of eukaryotic tubulin.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Kundu S, Kim TH, Yoon JH, Shin HS, Lee J, Jung JH, Kim HS. Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells. Int J Oncol. 2014 Dec;45(6):2331-40. doi: 10.3892/ijo.2014.2659. Epub 2014 Sep 17. PubMed PMID: 25231051.

[2]Liu Y, Kurtán T, Yun Wang C, Han Lin W, Orfali R, Müller WE, Daletos G, Proksch P. Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides. J Antibiot (Tokyo). 2016 Sep;69(9):702-6. doi: 10.1038/ja.2016.11. Epub 2016 Feb 24. PubMed PMID: 26905758.

[3] Grove CI, Shaw JT. Second-Generation Synthesis of (-)-Viriditoxin. Synthesis (Stuttg). 2012;2012(3):362-371. PubMed PMID: 23049144; PubMed Central PMCID: PMC3461596.

[4] Park YS, Grove CI, González-López M, Urgaonkar S, Fettinger JC, Shaw JT. Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ. Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3730-3. doi: 10.1002/anie.201007298. Epub 2011 Mar 16. PubMed PMID: 21413107; PubMed Central PMCID: PMC3325170.

[5] Fabiano RJ, Tu AT. Purification and biochemical study of viriditoxin, tissue damaging toxin, from prairie rattlesnake venom. Biochemistry. 1981 Jan 6;20(1):21-7. PubMed PMID: 6781535.

6: Lillehoj EB, Milburn MS. Viriditoxin production by Aspergillus viridi-nutans and related species. Appl Microbiol. 1973 Aug;26(2):202-5. PubMed PMID: 4582816; PubMed Central PMCID: PMC379751.7: Smyth JE, Butler NM, Keller PA. A twist of nature--the significance of atropisomers in biological systems. Nat Prod Rep. 2015 Nov;32(11):1562-83. doi: 10.1039/c4np00121d. Review. PubMed PMID: 26282828.8: Hood RD, Hayes AW, Scammell JG. Effects of prenatal administration of citrinin and viriditoxin to mice. Food Cosmet Toxicol. 1976 Jun;14(3):175-8. PubMed PMID: 950209.9: Wong DT, Hamill RL. Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria. Biochem Biophys Res Commun. 1976 Jul 12;71(1):332-8. PubMed PMID: 134706.10: Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, González A, Cully D, Bramhill D, Singh S. Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem. 2003 Nov 7;278(45):44424-8. Epub 2003 Sep 2. PubMed PMID: 12952956.1

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