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Velaresol

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names：
5-(2-formyl-3-hydroxyphenoxy)pentanoic acid
CAS號：
77858-21-0
MDL Number：
MF(分子式)： C12H14O5 MW(分子量)： 238.239
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	5-(2-formyl-3-hydroxyphenoxy)pentanoic acid
英文別名	Velaresol; BW 12C79; BW-12C79; BW12C79; BW 12C; BW-12C; BW12C.
CAS號	77858-21-0
Inchi	InChI=1S/C12H14O5/c13-8-9-10(14)4-3-5-11(9)17-7-2-1-6-12(15)16/h3-5,8,14H,1-2,6-7H2,(H,15,16)
InchiKey	NSUDGNLOXMLAEB-UHFFFAOYSA-N
分子式 Formula	C12H14O5
分子量 Molecular Weight	238.239
溶解度Solubility
性狀	Yellow solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Velaresol(CAS:77858-21-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Velaresol, also known as BW12C or BW12C79, is a oxyhaemoglobin stabilizer. Velaresol stabilizes oxyhaemoglobin also protect sickle cells against calcium-mediated dehydration.Velaresol causes a reversible left-shift of the oxygen saturation curve (OSC) and tissue hypoxia.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護(hù)
備注

[1]Philip PA, Thompson CH, Carmichael J, Rea D, Mitchell K, Taylor DJ, Stuart NS, Dennis I, Rajagopalan B, Ganesan T, et al. A phase I study of the left-shifting agent BW12C79 plus mitomycin C and the effect on the skeletal muscle metabolism using 31P magnetic resonance spectroscopy. Cancer Res. 1993 Dec 1;53(23):5649-53. PubMed PMID: 8242619.

[2]Trudel M, De Paepe ME, Chrétien N, Saadane N, Jacmain J, Sorette M, Hoang T, Beuzard Y. Sickle cell disease of transgenic SAD mice. Blood. 1994 Nov 1;84(9):3189-97. PubMed PMID: 7949191.

[3] Gibson JS, Khan A, Speake PF, Ellory JC. O2 dependence of K+ transport in sickle cells: the effect of different cell populations and the substituted benzaldehyde 12C79. FASEB J. 2001 Mar;15(3):823-32. PubMed PMID: 11259401.

[4] Propper DJ, Levitt NC, O'Byrne K, Braybrooke JP, Talbot DC, Ganesan TS, Thompson CH, Rajagopalan B, Littlewood TJ, Dixon RM, Harris AL. Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer. Br J Cancer. 2000 Jun;82(11):1776-82. PubMed PMID: 10839290; PubMed Central PMCID: PMC2363221.

[5] Muzyamba MC, Speake PF, Gibson JS. Oxidants and regulation of K(+)-Cl(-) cotransport in equine red blood cells. Am J Physiol Cell Physiol. 2000 Oct;279(4):C981-9. PubMed PMID: 11003578.

6: Gibson JS, Speake PF, Ellory JC. Effect of the substituted benzaldehyde 12C79 on Cl--dependent K+ influx in human red blood cells. Pflugers Arch. 1999 Feb;437(3):498-500. PubMed PMID: 9914409.7: Keidan AJ, Sowter MC, Johnson CS, Marwah SS, Stuart J. Pharmacological modification of oxygen affinity improves deformability of deoxygenated sickle erythrocytes: a possible therapeutic approach to sickle cell disease. Clin Sci (Lond). 1989 Apr;76(4):357-62. PubMed PMID: 2714049.8: Wootton R, Stammers DK, White RD. Reduction in potency and reversal of left-shifting activity of BW12C with the major and minor components of chicken hemoglobin. FEBS Lett. 1986 Dec 1;209(1):129-33. PubMed PMID: 3803572.9: Stevens G, Hill SA, Joiner MC, Joiner B, Johns H, Williams K, Denekamp J, Nethersell AB. The effect of BW12C on the radiosensitivity and necrosis of murine tissues and tumours. Australas Radiol. 1994 Aug;38(3):199-203. PubMed PMID: 7945114.10: Falk SJ, Ramsay JR, Ward R, Miles K, Dixon AK, Bleehen NM. BW12C perturbs normal and tumour tissue oxygenation and blood flow in man. Radiother Oncol. 1994 Sep;32(3):210-7. PubMed PMID: 7816940.1

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