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Tryptophyl adenylate

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names：
(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-((phosphonooxy)methyl)tetrahydrofuran-3-yl L-tryptophanate
CAS號：
31528-64-0
MDL Number：
MF(分子式)： C21H24N7O8P MW(分子量)： 533.43
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-((phosphonooxy)methyl)tetrahydrofuran-3-yl L-tryptophanate
英文別名	Tryptophyl adenylate;
CAS號	31528-64-0
Inchi	1S/C21H24N7O8P/c22-12(5-10-6-24-13-4-2-1-3-11(10)13)21(30)36-17-14(7-34-37(31,32)33)35-20(16(17)29)28-9-27-15-18(23)25-8-26-19(15)28/h1-4,6,8-9,12,14,16-17,20,24,29H,5,7,22H2,(H2,23,25,26)(H2,31,32,33)/t12-,14+,16+,17+,20+/m0/s1
InchiKey	ZTKQHOGBACRMGC-SQIXAUHQSA-N
分子式 Formula	C21H24N7O8P
分子量 Molecular Weight	533.43
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Tryptophyl adenylate(CAS:31528-64-0):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Tryptophyl adenylate is a bioactive chemical.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Merle M, Trezeguet V, Graves PV, Andrews D, Muench KH, Labouesse B. Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli. Biochemistry. 1986 Mar 11;25(5):1115-23. PubMed PMID: 3516215.

[2]Mazat JP, Merle M, Graves PV, Merault G, Gandar JC, Labouesse B. Kinetic anticooperativity in pre-steady-state formation of tryptophanyl adenylate by tryptophanyl-tRNA synthetase from beef pancreas. A consequence of the tryptophan anticooperative binding. Eur J Biochem. 1982 Nov 15;128(2-3):389-98. PubMed PMID: 7151786.

[3] Koh CY, Kim JE, Napoli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Hol WG. Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol. 2013 May;189(1-2):26-32. doi: 10.1016/j.molbiopara.2013.04.007. Epub 2013 May 7. PubMed PMID: 23665145; PubMed Central PMCID: PMC3680109.

[4] Merault G, Labouesse J, Graves PV, Labouesse B. Kinetics of formation of tryptophanyl-adenylate by tryptophanyl-tRNA synthetase from beef pancreas. FEBS Lett. 1981 Jan 26;123(2):165-8. PubMed PMID: 6112162.

[5] Favorova OO, Madoyan IA, Drutsa VL. "Half-site" affinity modification of tryptophanyl-tRNA synthetase leads to "freezing" of the free subunit. FEBS Lett. 1981 Jan 26;123(2):161-4. PubMed PMID: 6262106.

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