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Tosagestin

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names：
17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one
CAS號：
110072-15-6
MDL Number：
MF(分子式)： C21H24O2 MW(分子量)： 308.421
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

貨品編碼	規(guī)格	純度	價格 (￥)	現(xiàn)價(￥)	特價(￥)	庫存描述	數(shù)量	總計 (￥)
FMK20266-100mg	100mg	>98%	￥ 0.00	￥ 0.00		Get quote	- +	￥ 0.00

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中文別名	17-Hydroxy-11-methylene-19-nor-17alpha-pregna-4,15-dien-20-yn-3-one
英文別名	Tosagestin; Org-30659; Org 30659; Org30659.
CAS號	110072-15-6
Inchi	InChI=1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21+/m0/s1
InchiKey	YJSTYQGZKJHXLN-LEZSPFLNSA-N
分子式 Formula	C21H24O2
分子量 Molecular Weight	308.421
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Tosagestin(CAS:110072-15-6):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Tosagestin, also known as Org-30659, is a progesterone receptor agonist potentially use in contraception. Daily oral administration of 0.060-0.240 mg of Org 30659 suppresses ovarian function to a level sufficient to inhibit ovulation.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Nieuwmeyer F, van der Voort Maarschalk K, Vromans H. Lactose contaminant as steroid degradation enhancer. Pharm Res. 2008 Nov;25(11):2666-73. doi: 10.1007/s11095-008-9687-z. Epub 2008 Aug [1]PubMed PMID: 18670867.

[2]de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, Machielsen CS, Uchida E, Cohen AF. Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE). Contraception. 2003 Sep;68(3):195-202. PubMed PMID: 14561540.

[3] Verhoeven CH, van Munster TT, Groothuis GM, Vos RM, Rietjens IM. Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Xenobiotica. 2002 Feb;32(2):109-18. PubMed PMID: 11871398.

[4] Obruca A, Korver T, Huber J, Killick SR, Landgren B, Struijs MJ. Ovarian function during and after treatment with the new progestagen Org 30659. Fertil Steril. 2001 Jul;76(1):108-15. PubMed PMID: 11438328.

[5] Verhoeven CH, Gloudemans RH, Groothuis GM, Rietjens IM, Vos RM. Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. J Steroid Biochem Mol Biol. 2000 May;73(1-2):39-48. PubMed PMID: 10822023.

6: Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM. In vitro and in vivo metabolism of the progestagen Org 30659 in several species. Drug Metab Dispos. 1998 Nov;26(11):1102-12. PubMed PMID: 9806953.7: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):439-44. PubMed PMID: 8541241.8: Schoonen WG, Joosten JW, Kloosterboer HJ. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines. J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):423-37. PubMed PMID: 8541240.9: van der Burg B, Kalkhoven E, Isbrücker L, de Laat SW. Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. PubMed PMID: 1616875.

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