久久免费视频6,久久久一本精品久久精品六六,亚洲码国产精品高潮在线

TMC647055

NMR下載 COA and HPLC MSDS下載
names：
2,19-Methano-3,74,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide
CAS號(hào)：
1204416-97-6
MDL Number：
MF(分子式)： C32H38N4O6S MW(分子量)： 606.738
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

貨品編碼	規(guī)格	純度	價(jià)格 (￥)	現(xiàn)價(jià)(￥)	特價(jià)(￥)	庫(kù)存描述	數(shù)量	總計(jì) (￥)

大包裝詢價(jià) 提供各種包裝，敬請(qǐng)垂詢
收藏商品商品點(diǎn)評(píng) 加入購(gòu)物車立即購(gòu)買

快速詢價(jià)

收起

你想詢價(jià)的產(chǎn)品

*產(chǎn)品名稱：

CAS號(hào)：

產(chǎn)品編號(hào)：

需求描述：

請(qǐng)準(zhǔn)確填寫您的聯(lián)系方式，以便為您提供最好的服務(wù)。

*公司名稱：

*電子郵箱：

聯(lián)系人：

*電話：

*驗(yàn)證碼：

詢價(jià)

中文別名	2,19-Methano-3,74,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide
英文別名	TMC-647055; TMC 647055; TMC647055.
CAS號(hào)	1204416-97-6
Inchi	InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
InchiKey	UOBYJVFBFSLCTQ-UHFFFAOYSA-N
分子式 Formula	C32H38N4O6S
分子量 Molecular Weight	606.738
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	TMC647055(CAS:1204416-97-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	TMC647055 is a potent HCV NS5B polymerase inhibitor potentially for the treatment of HCV infection. TMC647055 has nanomolar cellular potency (EC(50) of 82 nM) with minimal associated cell toxicity (CC(50)>20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation. TMC647055 is currently being evaluated in the clinic.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Wang H, Cui W, Guo C, Chen BZ, Ji M. Molecular modeling study on the drugresistance mechanism of NS5B polymerase to TMC647055. Biochem Cell Biol. 2016Apr;94(2):147-58. doi: 10.1139/bcb-2015-0109. PubMed PMID: 26836778.

[2]Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, DevogelaereB, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der HelmL, Fanning G, Nyanguile O, Simmen K, Van Remoortere P, Raboisson P, Vendeville S.Discovery and early development of TMC647055, a non-nucleoside inhibitor of thehepatitis C virus NS5B polymerase. J Med Chem. 2014 Mar 13;57(5):1880-92. doi:10.1021/jm401396p. PubMed PMID: 24144360.

[3] Devogelaere B, Berke JM, Vijgen L, Dehertogh P, Fransen E, Cleiren E, van derHelm L, Nyanguile O, Tahri A, Amssoms K, Lenz O, Cummings MD, Clayton RF,Vendeville S, Raboisson P, Simmen KA, Fanning GC, Lin TI. TMC647055, a potentnonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypiccoverage. Antimicrob Agents Chemother. 2012 Sep;56(9):4676-84. doi:10.1128/AAC.00245-12. PubMed PMID: 22710121; PubMed Central PMCID: PMC3421868.

[4] Vendeville S, Lin TI, Hu L, Tahri A, McGowan D, Cummings MD, Amssoms K, CanardM, Last S, Van den Steen I, Devogelaere B, Rouan MC, Vijgen L, Berke JM,Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Van Emelen K,Nyanguile O, Simmen K, Raboisson P. Finger loop inhibitors of the HCV NS5bpolymerase. Part II. Optimization of tetracyclic indole-based macrocycle leadingto the discovery of TMC647055. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4437-43.doi: 10.1016/j.bmcl.2012.04.113. PubMed PMID: 22633687.

對(duì)不起，暫無(wú)產(chǎn)品評(píng)價(jià)！

MSDS

SDS 1.0 中文

展開

SDS 1.0 英文

展開