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TB-2-081

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names：
3-O-Formyl-20R,21-epoxyresibufogenin
CAS號：
451470-55-6
MDL Number：
MF(分子式)： C25H32O6 MW(分子量)： 428.53
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	3-O-Formyl-20R,21-epoxyresibufogenin
英文別名	TB-2-081; TB2081; TB 2 081; TB-2081; TB2-081; TB 2-081; TB-2 081
CAS號	451470-55-6
Inchi	InChI=1S/C25H32O6/c1-22-8-5-15(28-13-26)11-14(22)3-4-17-16(22)6-9-23(2)18(12-19-25(17,23)30-19)24-10-7-20(27)29-21(24)31-24/h7,10,13-19,21H,3-6,8-9,11-12H2,1-2H3/t14-,15+,16+,17-,18-,19-,21+,22+,23-,24-,25-/m1/s1
InchiKey	CMYYMVGNLZUIOQ-AYFUEPLASA-N
分子式 Formula	C25H32O6
分子量 Molecular Weight	428.53
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	TB-2-081(CAS:451470-55-6):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	TB-2-081 is a antagonist of IL-6 signaling.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Remeniuk B, King T, Sukhtankar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. Pain. 2018 Apr;159(4):684-698. doi: 10.1097/j.pain.0000000000001139. PubMed PMID: 29300279; PubMed Central PMCID: PMC5911943.

[2]Boos TL, Cheng K, Greiner E, Deschamps JR, Jacobson AE, Rice KC. Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate. J Nat Prod. 2012 Apr 27;75(4):661-8. doi: 10.1021/np2008957. Epub 2012 Feb 23. PubMed PMID: 22360661; PubMed Central PMCID: PMC3351795.

[3] Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 2010 Nov;151(2):257-65. doi: 10.1016/j.pain.2010.05.022. Epub 2010 Jul 4. PubMed PMID: 20599324; PubMed Central PMCID: PMC3313485.

[4] Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC, Chrousos GP. 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications. J Allergy Clin Immunol. 2007 Aug;120(2):437-44. Epub 2007 Apr 23. PubMed PMID: 17451794.

[5] Hayashi M, Rho MC, Fukami A, Enomoto A, Nonaka S, Sekiguchi Y, Yanagisawa T, Yamashita A, Nogawa T, Kamano Y, Komiyama K. Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate. J Pharmacol Exp Ther. 2002 Oct;303(1):104-9. PubMed PMID: 12235239.

6: Li W, Shi X, Wang L, Guo T, Wei T, Cheng K, Rice KC, Kingery WS, Clark JD. Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome. Pain. 2013 Aug;154(8):1224-36. doi: 10.1016/j.pain.2013.03.033. Epub 2013 Apr 12. PubMed PMID: 23718987; PubMed Central PMCID: PMC3713848.

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