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S-Nitrosohomocysteine

NMR下載 COA and HPLC MSDS下載
names：
S-nitroso-L-homocysteine
CAS號(hào)：
139427-42-2
MDL Number：
MF(分子式)： C4H8N2O3S MW(分子量)： 164.17
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	S-nitroso-L-homocysteine
英文別名	S-Nitrosohomocysteine;
CAS號(hào)	139427-42-2
Inchi	InChI=1S/C4H8N2O3S/c5-3(4(7)8)1-2-10-6-9/h3H,1-2,5H2,(H,7,8)/t3-/m0/s1
InchiKey	QWPCKAAAWDCDCW-VKHMYHEASA-N
分子式 Formula	C4H8N2O3S
分子量 Molecular Weight	164.17
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	S-Nitrosohomocysteine(CAS:139427-42-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	S-Nitrosohomocysteine is a DDAH Inhibitor.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Karver CE, Ahmed VF, Barrios AM. Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):285-7. doi: 10.1016/j.bmcl.2010.11.025. Epub 2010 Nov 9. PubMed PMID: 21129966.

[2]Morakinyo MK, Strongin RM, Simoyi RH. Modulation of homocysteine toxicity by S-nitrosothiol formation: a mechanistic approach. J Phys Chem B. 2010 Aug 5;114(30):9894-904. doi: 10.1021/jp103679v. PubMed PMID: 20666529.

[3] Hong L, Fast W. Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. J Biol Chem. 2007 Nov 30;282(48):34684-92. Epub 2007 Sep 24. PubMed PMID: 17895252.

[4] Chobanyan K, Thum T, Suchy MT, Zhu B, Mitschke A, Gutzki FM, Beckmann B, Stichtenoth DO, Tsikas D. GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):32-41. Epub 2007 Aug 7. PubMed PMID: 17825631.

[5] Braun O, Knipp M, Chesnov S, Vasák M. Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase. Protein Sci. 2007 Aug;16(8):1522-34. Epub 2007 Jun 28. PubMed PMID: 17600152; PubMed Central PMCID: PMC2203367.

6: Broniowska KA, Zhang Y, Hogg N. Requirement of transmembrane transport for S-nitrosocysteine-dependent modification of intracellular thiols. J Biol Chem. 2006 Nov 10;281(45):33835-41. Epub 2006 Aug 7. PubMed PMID: 16893892; PubMed Central PMCID: PMC1839924.7: Frey D, Braun O, Briand C, Vasák M, Grütter MG. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure. 2006 May;14(5):901-11. PubMed PMID: 16698551.8: Zhang Y, Hogg N. S-Nitrosothiols: cellular formation and transport. Free Radic Biol Med. 2005 Apr 1;38(7):831-8. Review. PubMed PMID: 15749378.9: Knipp M, Braun O, Vasák M. Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead. J Am Chem Soc. 2005 Mar 2;127(8):2372-3. PubMed PMID: 15724974.10: Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM. Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J Biol Chem. 2005 Feb 18;280(7):5781-8. Epub 2004 Nov 23. PubMed PMID: 15561702.1

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