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Sinitrodil

NMR下載 COA and HPLC MSDS下載
names：
2-(4-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl nitrate
CAS號(hào)：
143248-63-9
MDL Number：
MF(分子式)： C10H10N2O5 MW(分子量)： 238.19
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	2-(4-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl nitrate
英文別名	ITF-296; ITF296; ITF 296
CAS號(hào)	143248-63-9
Inchi	InChI=1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2
InchiKey	POVFCWQCRHXYAB-UHFFFAOYSA-N
分子式 Formula	C10H10N2O5
分子量 Molecular Weight	238.19
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	Sinitrodil(CAS:143248-63-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	Sinitrodil is a guanylate cyclase stimulant potentially for the treatment of myocardial ischaemia and angina
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Minghetti P, Casiraghi A, Montanari L, Monzani MV. In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs. Eur J Pharm Sci. 1999 Feb;7(3):231-6. PubMed PMID: 9845810.

[2]Monzani MV, Coltro G, Sala A, Sardina M. Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. Eur J Pharm Sci. 1999 Feb;7(3):179-84. PubMed PMID: 9845803.

[3] Van Bortel LM, Spek JJ, Balkestein EJ, Sardina M, Struijker Boudier HA. Is it possible to develop drugs that act more selectively on large arteries? J Hypertens. 1999 May;17(5):701-5. PubMed PMID: 10403615.

[4] Khattar RS, Senior R, Sardina M, Boyce M, Lahiri A. Safety, tolerability, and antiischaemic efficacy of ITF-296, a nitric oxide donor, in patients with chronic stable angina. J Cardiovasc Pharmacol. 1998 Aug;32(2):295-9. PubMed PMID: 9700993.

[5] Giachetti C, Bertolino M, Canali S, Lombardini E, Monzani MV, Sala A, Zanolo G. Pharmacokinetic study in rats after single intravenous and oral administrations of [14C]-ITF-296. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):230-8. PubMed PMID: 9725487.

6: Giachetti C, Bertolino M, Canali S, Lombardini E, Monzani MV, Sala A, Zanolo G. Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):239-50. PubMed PMID: 9725488.7: Monzani MV, Coltro G, Jiritano L, Sala A. Simultaneous determination of ITF 296 and two metabolites in plasma by a validated HPLC method. Boll Chim Farm. 1997 Apr;136(4):382-8. PubMed PMID: 9281893.8: Duncker DJ, Mizrahi J, Bache RJ. Nitrovasodilators ITF 296 and isosorbide dinitrate exert antiischemic activity by dilating coronary penetrating arteries. J Cardiovasc Pharmacol. 1995 May;25(5):823-32. PubMed PMID: 7630161.9: Sardina M, Love R, Mizrahi J, Monzani V, Bianchini C. Safety and pharmacologic activity of a new nitrate ester, ITF 296, after intravenous administration in healthy volunteers. J Cardiovasc Pharmacol. 1995;26 Suppl

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