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SG-209

NMR下載 COA and HPLC MSDS下載
names：
N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide
CAS號(hào)：
83440-03-3
MDL Number：
MF(分子式)： C10H12N2O3 MW(分子量)： 208.21
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide
英文別名	SG-209; SG 209; SG209;
CAS號(hào)	83440-03-3
Inchi	InChI=1S/C10H12N2O3/c1-8(13)15-6-5-12-10(14)9-3-2-4-11-7-9/h2-4,7H,5-6H2,1H3,(H,12,14)
InchiKey	JQICNNKLTFYSLS-UHFFFAOYSA-N
分子式 Formula	C10H12N2O3
分子量 Molecular Weight	208.21
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	SG-209(CAS:83440-03-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	SG-209 is a potassium channel opener.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
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[1]Umaru B, Pyriochou A, Kotsikoris V, Papapetropoulos A, Topouzis S. ATP-sensitive potassium channel activation induces angiogenesis in vitro and in vivo. J Pharmacol Exp Ther. 2015 Jul;354(1):79-87. doi: 10.1124/jpet.114.222000. Epub 2015 May 14. PubMed PMID: 25977483.

[2]Parimala K, Peedicayil J, Peedicayil A, Nelson N, Ernest K. The effect of a nicorandil congener on isolated human myometrium. Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):176-9. Epub 2005 Oct 10. PubMed PMID: 16216408.

[3] Wei XM, Heywood GJ, Di Girolamo N, Thomas PS. Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes. Int Immunopharmacol. 2003 Nov;3(12):1581-8. PubMed PMID: 14555283.

[4] Heywood GJ, Thomas PS. Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells. Inflamm Res. 2002 Apr;51(4):176-81. PubMed PMID: 12058954.

[5] Satoh K, Orito K, Yoneyama F, Taira N. A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart. Cardiovasc Drugs Ther. 1994 Apr;8(2):227-34. PubMed PMID: 7918135.

6: Abe S, Nishimura J, Nakamura M, Kanaide H. Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery. J Pharmacol Exp Ther. 1994 Feb;268(2):762-71. PubMed PMID: 8113988.7: Satoh K, Yamada H, Yoneyama F, Taira N. The group at C2 of N-ethylnicotinamide determines the vasodilator potencies and mechanisms of action of nicorandil and its congeners in canine coronary arteries. Naunyn Schmiedebergs Arch Pharmacol. 1991 Nov;344(5):589-95. PubMed PMID: 1839805.8: Ishibashi T, Hamaguchi M, Imai S. 2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives. Naunyn Schmiedebergs Arch Pharmacol. 1991 Aug;344(2):235-9. PubMed PMID: 1658666.9: Yonekura H, Iwatsuki K, Horiuchi A, Chiba S. Effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog. Pancreas. 1990;5(1):75-81. PubMed PMID: 1688393.10: Maruyama M, Satoh K, Taira N. Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ. Arch Int Pharmacodyn Ther. 1982 Aug;258(2):260-6. PubMed PMID: 6215905.

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