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Selenazofurin
- names：
2-beta-D-Ribofuranosyl-4-selenazolecarboxamide
- CAS號：
83705-13-9
MDL Number： - MF(分子式)： C9H12N2O5Se MW(分子量)： 307.16
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
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| 中文別名 | 2-beta-D-Ribofuranosyl-4-selenazolecarboxamide |
| 英文別名 | Selenazofurin; BRN 4198668; CI-935; CI 935; CI935. |
| CAS號 | 83705-13-9 |
| Inchi | |
| InchiKey | |
| 分子式 Formula | C9H12N2O5Se |
| 分子量 Molecular Weight | 307.16 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Selenazofurin(CAS:83705-13-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Selenazofurin is an antiviral compound used against influenza A and B viruses. Selenazofurin inhibits the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4). |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Pogrebniak A, Hasmann M, Schemainda I, Pelka-Fleischer R, Nuessler V. Cytoprotective features of selenazofurin in hematopoietic cells. Int J Clin Pharmacol Ther. 2002 Aug;40(8):368-75. PubMed PMID: 12467305. |
| [2]Franchetti P, Cappellacci L, Sheikha GA, Jayaram HN, Gurudutt VV, Sint T, Schneider BP, Jones WD, Goldstein BM, Perra G, De Montis A, Loi AG, La Colla P, Grifantini M. Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. J Med Chem. 1997 May 23;40(11):1731-7. PubMed PMID: 9171883. |
| [3] Gharehbaghi K, Sreenath A, Hao Z, Paull KD, Szekeres T, Cooney DA, Krohn K, Jayaram HN. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin. Biochem Pharmacol. 1994 Oct 7;48(7):1413-9. PubMed PMID: 7945441. |
| [4] Smee DF, Gilbert J, Leonhardt JA, Barnett BB, Huggins JH, Sidwell RW. Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen. Antiviral Res. 1993 Jan;20(1):57-70. PubMed PMID: 8384433. |
| [5] Parandoosh Z, Robins RK, Belei M, Rubalcava B. Tiazofurin and selenazofurin induce depression of cGMP and phosphatidylinositol pathway in L1210 leukemia cells. Biochem Biophys Res Commun. 1989 Oct 31;164(2):869-74. PubMed PMID: 2554903. |
6: Sidwell RW, Huffman JH, Call EW, Alaghamandan H, Cook PD, Robins RK. Effect of selenazofurin on influenza A and B virus infections of mice. Antiviral Res. 1986 Oct;6(6):343-53. PubMed PMID: 3022644.7: Wray SK, Smith RH, Gilbert BE, Knight V. Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses. Antimicrob Agents Chemother. 1986 Jan;29(1):67-72. PubMed PMID: 3729336; PubMed Central PMCID: PMC180366.8: Lee HJ, Pawlak K, Nguyen BT, Robins RK, Sadée W. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer Res. 1985 Nov;45(11 Pt 1):5512-20. PubMed PMID: 2865005.9: Sidwell RW, Huffman JH, Call EW, Alaghamandan H, Cook PD, Robins RK. Activity of selenazofurin against influenza A and B viruses in vitro. Antimicrob Agents Chemother. 1985 Sep;28(3):375-7. PubMed PMID: 4073860; PubMed Central PMCID: PMC180256.10: Berger NA, Berger SJ, Catino DM, Petzold SJ, Robins RK. Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin. A new strategy for cancer chemotherapy. J Clin Invest. 1985 Feb;75(2):702-9. PubMed PMID: 3919063; PubMed Central PMCID: PMC423562.1
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