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Sch 42495

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names：
N-(2(S)-(Acetylthiomethyl)-3-(2-methylphenyl)-1-oxopropyl)-L-methionine ethyl ester
CAS號：
136511-43-8
MDL Number：
MF(分子式)： C20H29NO4S2 MW(分子量)： 411.58
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	N-(2(S)-(Acetylthiomethyl)-3-(2-methylphenyl)-1-oxopropyl)-L-methionine ethyl ester
英文別名	Sch 42495; Sch-42495; Sch42495.
CAS號	136511-43-8
Inchi
InchiKey
分子式 Formula	C20H29NO4S2
分子量 Molecular Weight	411.58
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Sch 42495(CAS:136511-43-8):僅限應用于工業(yè)或者科學研究過程中非醫(yī)療目的，不應用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Sch 42495 is a neutral endopeptidase inhibitor.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Stuhr LE. Effects of SCH 42495, a neutral endopeptidase inhibitor, on cardiac function and mass in rats after repeated hyperbaric exposures. Scand J Clin Lab Invest. 2000 Apr;60(2):141-8. PubMed PMID: 10817401.

[2]SCH 42495. Drugs R D. 1999 Apr;1(4):354-6. PubMed PMID: 10566064.

[3] Burrell LM, Farina N, Risvanis J, Woollard D, Casely D, Johnston CI. Inhibition of neutral endopeptidase, the degradative enzyme for natriuretic peptides, in rat kidney after oral SCH 42495. Clin Sci (Lond). 1997 Jul;93(1):43-50. PubMed PMID: 9279202.

[4] Ogihara T, Rakugi H, Masuo K, Yu H, Nagano M, Mikami H. Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension. Am J Hypertens. 1994 Nov;7(11):943-7. PubMed PMID: 7848619.

[5] Thompson JS, Sheedy W, Morice AH. Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats. Clin Sci (Lond). 1994 Jul;87(1):109-14. PubMed PMID: 8062513.

6: Sala C, Monopoli A, Casati C, Ardeleani G, Ongini E, Zanchetti A, Morganti A. Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1994 May;23(5):703-8. PubMed PMID: 7521451.7: Richards AM, Crozier IG, Kosoglou T, Rallings M, Espiner EA, Nicholls MG, Yandle TG, Ikram H, Frampton C. Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26. PubMed PMID: 8391513.8: Watkins RW, Vemulapalli S, Chiu PJ, Foster C, Smith EM, Neustadt B, Haslanger M, Sybertz EJ. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. PubMed PMID: 8512660.9: Alton KB, Hernandez A, Alvarez N, Patrick JE. High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric detector. J Chromatogr. 1992 Sep 2;579(2):307-17. PubMed PMID: 1429978.

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