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Rubratoxin B

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names：
4-hydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-5,9,10,11-tetrahydro-1H-cyclonona[1,2-c5,6-c']difuran-1,3,6,8(4H)-tetraone
CAS號：
21794-01-4
MDL Number：
MF(分子式)： C26H30O11 MW(分子量)： 518.51
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	4-hydroxy-10-(hydroxy(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl)-5-(1-hydroxyheptyl)-5,9,10,11-tetrahydro-1H-cyclonona[1,2-c5,6-c']difuran-1,3,6,8(4H)-tetraone
英文別名	Rubratoxin B;
CAS號	21794-01-4
Inchi	InChI=1S/C26H30O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-22,27,29-30H,2-5,7-8,10-11H2,1H3
InchiKey	ZJTBTDVZNGBSNG-UHFFFAOYSA-N
分子式 Formula	C26H30O11
分子量 Molecular Weight	518.51
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Rubratoxin B(CAS:21794-01-4):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has shown anticancer activity.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Nagashima H. Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells. Environ Toxicol Pharmacol. 2015 Nov;40(3):997-1000. doi: 10.1016/j.etap.2015.10.012. Epub 2015 Nov 2. PubMed PMID: 26595743.

[2]Iwashita K, Nagashima H. Rubratoxin B induces signs of fatty acid oxidation disorders (FAODs) in mice. Toxicol Lett. 2011 Oct 10;206(2):238-43. doi: 10.1016/j.toxlet.2011.07.027. Epub 2011 Jul 30. PubMed PMID: 21835235.

[3] Nagashima H, Nakamura K, Goto T. Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells. Biochem Biophys Res Commun. 2001 Oct 5;287(4):829-32. PubMed PMID: 11573937.

[4] Iwashita K, Nagashima H. Rubratoxin B induces interleukin-6 secretion in mouse white adipose tissues and 3T3-L1 adipocytes. Toxicol Lett. 2008 Nov 10;182(1-3):79-83. doi: 10.1016/j.toxlet.2008.08.008. Epub 2008 Aug 29. PubMed PMID: 18804154.

[5] Nagashima H, Nakamura K, Goto T. Rubratoxin B induced the secretion of hepatic injury-related colony stimulating factors in human hepatoma cells. Toxicol Lett. 2003 Nov 30;145(2):153-9. PubMed PMID: 14581167.

6: Phillips TD, Hayes AW. Structural modification of polyfunctional rubratoxin B: effects on mammalian adenosine triphosphatase. J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):853-60. PubMed PMID: 217944.7: Nagashima H, Maeda-Nakamura K, Iwashita K, Goto T. Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B. Arch Toxicol. 2007 May;81(5):347-51. Epub 2006 Nov 16. PubMed PMID: 17109117.8: Unger PD, Hayes AW. High-pressure liquid chromatography of the mycotoxins, rubratoxins A and B, and its application to the analysis of urine and plasma for rubratoxin B. J Chromatogr. 1978 Jun 1;153(1):115-26. PubMed PMID: 580783.9: Nagashima H, Nakamura K, Goto T. Stress-activated MAP kinases regulate rubratoxin B-caused cytotoxicity and cytokine secretion in hepatocyte-derived HepG2 cells. Toxicol Lett. 2005 Feb 15;155(2):259-67. PubMed PMID: 15603921.10: Wang T, Zhang Y, Wang Y, Pei YH. Anti-tumor effects of Rubratoxin B on cell toxicity, inhibition of cell proliferation, cytotoxic activity and matrix metalloproteinase-2,9. Toxicol In Vitro. 2007 Jun;21(4):646-50. Epub 2007 Jan 11. PubMed PMID: 17306501.1

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