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RFCNU

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names：
Urea, N-(2-chloroethyl)-N'-(2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)ribofuranosyl)-N-nitroso-
CAS號：
56194-22-0
MDL Number：
MF(分子式)： C18H21ClN4O9 MW(分子量)： 472.835
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Urea, N-(2-chloroethyl)-N'-(2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)ribofuranosyl)-N-nitroso-
英文別名	RFCNU
CAS號	56194-22-0
Inchi	InChI=1S/C18H21ClN4O9/c1-18(2)31-13-12(9-29-16(24)10-3-5-11(6-4-10)23(27)28)30-15(14(13)32-18)20-17(25)22(21-26)8-7-19/h3-6,12-15H,7-9H2,1-2H3,(H,20,25)/t12-,13-,14-,15?/m1/s1
InchiKey	YASNUXZKZNVXIS-CBNXCZCTSA-N
分子式 Formula	C18H21ClN4O9
分子量 Molecular Weight	472.835
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	RFCNU(CAS:56194-22-0):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	RFCNU is a nitrosourea derivative.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Bourut C, Chenu E, Godenèche D, Madelmont JC, Maral R, Mathé G, Meyniel G. Cytostatic action of two nitrosoureas derived from cysteamine. Br J Pharmacol. 1986 Nov;89(3):539-46. PubMed PMID: 3801787; PubMed Central PMCID: PMC1917164.

[2]Andrade Mena CE, Orbach-Arbouys S, Cosmatopoulos K, Mathé G. Effects of three new nitrosourea analogs (CNCC, RFCNU and chlorozotocin) on in vivo destruction of L 1210 leukemia cells and on the immune response. Chemotherapy. 1986;32(2):131-7. PubMed PMID: 2938892.

[3] Maral R, Bourut C, Chenu E, Mathe G, Bernon R, Lussan C, Imbach JL, Schein P, Bothorel P. Comparison of the experimental antitumor activities of three nitrosourea derivatives chlorozotocin, RFCNU and CNCC encapsulated in liposomes with those in the free state. Oncology. 1985;42(2):122-8. PubMed PMID: 3157909.

[4] Blazsek I, Mathé G, Maral R, Jasmin C. In vivo acute hematotoxicity of N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cystamine (CNCC), a new nitrosourea analog. Toxicol Appl Pharmacol. 1984 Jun 30;74(2):250-7. PubMed PMID: 6740675.

[5] Rebischung JL, Gougeon MD, Mori KJ, Lemaigre G, Mathé G, Jasmin C. Hematological toxicity of repeated injections of (chloro-2-ethyl)-ribofuranosyl-3-nitrosourea. Cancer Res. 1984 Feb;44(2):503-6. PubMed PMID: 6692356.

6: Florentin I, Hayat M, Kiger N, Mathé G, Maral J, Imbach JL. Comparative analysis of the immunopharmacological properties of three new nitrosourea analogues: RPCNU, RFCNU and Chlorozotocin. Int J Immunopharmacol. 1983;5(3):201-10. PubMed PMID: 6225736.7: Madelmont JC, Moreau MF, Godeneche D, Duprat J, Plagne R, Meyniel G. Main metabolites of 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea and 1-(2-chloroethyl)-3-(2',3', 4'-tri-O-acetyl-alpha, beta-D-ribopyranosyl)-1-nitrosourea in rats. Drug Metab Dispos. 1982 Nov-Dec;10(6):662-6. PubMed PMID: 6130919.8: Mathé G, Schein PS, De Vassal F, Serrou B, Imbach JL. [Phase II study of 3 new nitrosoureas, 1 American (chlorozotocin) and 2 French (RFCNU and RPCNU)]. Sem Hop. 1982 Sep 16;58(33):1867-71. French. PubMed PMID: 6293062.9: Mathe G, Schein P, MacDonald JS, Imbach JL, Misset JL, De Vassal F, Ribaud P, Serrou B, Gouveia J, Musset M, Machover D, Schwarzenberg L, Jasmin C, de Jager R. Study of nitrosourea glycosyl analogs--V. An oriented phase II trial of RFCNU. Eur J Cancer Clin Oncol. 1982 Aug;18(8):727-32. PubMed PMID: 6891323.10: Mathé G, Bothorel P. In vivo enhancement of the experimental oncostatic effect of RFCNU by its encapsulation in liposomes. Biomedicine. 1981 Dec;35(7-8):201-2. PubMed PMID: 7346064.1

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