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Luffariellolide

NMR下載 COA and HPLC MSDS下載
names：
2(5H)-Furanone, 4-(4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl)-5-hydroxy-, (E,E)-
CAS號(hào)：
111149-87-2
MDL Number：
MF(分子式)： C25H38O3 MW(分子量)： 386.576
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Luffariellolide
英文別名	Luffariellolide
CAS號(hào)	111149-87-2
Inchi	InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InchiKey	JPWPYTMXSXYUPG-QZPYEDBESA-N
分子式 Formula	C25H38O3
分子量 Molecular Weight	386.576
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Luffariellolide(CAS:111149-87-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Luffariellolide is a partially reversible phospholipase A2 inhibitor; a major metabolite of the sponge Luffariella.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Li J, Du L, Kelly M, Zhou YD, Nagle DG. Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis. J Nat Prod. 2013 Aug 23;76(8):1492-7. doi: 10.1021/np400350k. Epub 2013 Aug 14. PubMed PMID: 23944963; PubMed Central PMCID: PMC3809078.

[2]McEwan IJ. What lies beneath: natural products from marine organisms as nuclear receptor modulators. Biochem J. 2012 Aug 15;446(1):e1-3. doi: 10.1042/BJ20121018. PubMed PMID: 22835216.

[3] Wang S, Wang Z, Lin S, Zheng W, Wang R, Jin S, Chen J, Jin L, Li Y. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J. 2012 Aug 15;446(1):79-87. doi: 10.1042/BJ20120726. PubMed PMID: 22642567.

[4] Cao S, Foster C, Lazo JS, Kingston DG. Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B. Bioorg Med Chem. 2005 Sep 1;13(17):5094-8. PubMed PMID: 15927472.

[5] Elkhayat E, Edrada R, Ebel R, Wray V, van Soest R, Wiryowidagdo S, Mohamed MH, Müller WE, Proksch P. New luffariellolide derivatives from the Indonesian sponge Acanthodendrilla sp. J Nat Prod. 2004 Nov;67(11):1809-17. PubMed PMID: 15568767.

6: Froldi G, Galzignato G, Zanetti M, Montopoli M, Dorigo P, Caparrotta L. Are prostanoids related to positive inotropism by UTP and ATP? Pharmacology. 2005 Mar;73(3):140-5. Epub 2004 Nov 24. PubMed PMID: 15564788.7: Glaser KB, Sung ML, Hartman DA, Lock YW, Bauer J, Walter T, Carlson RP. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. Skin Pharmacol. 1995;8(6):300-8. PubMed PMID: 8688196.8: Marshall LA, Murphy J, Marinari L, Chang J. Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis. Agents Actions. 1992 Sep;37(1-2):60-9. PubMed PMID: 1456181.9: Mann J. Natural products. Sponges to wipe away pain. Nature. 1992 Aug 13;358(6387):540. PubMed PMID: 1501709.10: Glaser KB, Lock YW, Chang JY. PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase. Agents Actions. 1991 Sep;34(1-2):89-92. PubMed PMID: 1665306.1

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