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LT175

NMR下載 COA and HPLC MSDS下載
names：
2(S)-(Biphenyl-4-yloxy)-3-phenyl-propionic acid
CAS號(hào)：
862901-87-9
MDL Number：
MF(分子式)： C21H18O3 MW(分子量)： 318.37
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	LT175
英文別名	LT175; LT-175; LT 175;
CAS號(hào)	862901-87-9
Inchi	InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1
InchiKey	TZTPJJNNACUQQR-FQEVSTJZSA-N
分子式 Formula	C21H18O3
分子量 Molecular Weight	318.37
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	LT175(CAS:862901-87-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	LT175 is a PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F. Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175. Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24. PubMed PMID: 25497132.

[2]Lori C, Pasquo A, Montanari R, Capelli D, Consalvi V, Chiaraluce R, Cervoni L, Loiodice F, Laghezza A, Aschi M, Giorgi A, Pochetti G. Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1965-76. doi: 10.1107/S1399004714009638. Epub 2014 Jun 29. PubMed PMID: 25004973.

[3] Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-20. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. PubMed PMID: 24451380; PubMed Central PMCID: PMC3945352.

[4] Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. doi: 10.1021/jm800733h. PubMed PMID: 19053776.

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