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LSL-60101

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names：
2-(2-Benzofuranyl)-1H-imidazole
CAS號(hào)：
150985-54-9
MDL Number：
MF(分子式)： C11H8N2O MW(分子量)： 184.198
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	LSL-60101
英文別名	LSL60101; LSL-60101; LSL 60101;
CAS號(hào)	150985-54-9
Inchi	InChI=1S/C11H8N2O/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11/h1-7H,(H,12,13)
InchiKey	VBFQIUOSXHUWCT-UHFFFAOYSA-N
分子式 Formula	C11H8N2O
分子量 Molecular Weight	184.198
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說(shuō)明	LSL-60101(CAS:150985-54-9):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。
Introduction	LSL60101 is a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.
Application1
Application2
Application3

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危險(xiǎn)性	Warning
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[1]Garau C, Miralles A, García-Sevilla JA. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain. J Psychopharmacol. 2013 Feb;27(2):123-34. doi: 10.1177/0269881112450785. Epub 2012 Jun 20. PMID: 22719017.

[2]Miralles A, Esteban S, Sastre-Coll A, Moranta D, Asensio VJ, García-Sevilla JA. High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. Eur J Pharmacol. 2005 Aug 22;518(2-3):234-42. doi: 10.1016/j.ejphar.2005.06.023. PMID: 16061219.

[3] Casanovas A, Olmos G, Ribera J, Boronat MA, Esquerda JE, García-Sevilla JA. Induction of reactive astrocytosis and prevention of motoneuron cell death by the I(2)-imidazoline receptor ligand LSL 60101. Br J Pharmacol. 2000 Aug;130(8):1767-76. doi: 10.1038/sj.bjp.0703485. PMID: 10952664; PMCID: PMC1572252.

[4] Sánchez-Blázquez P, Boronat MA, Olmos G, García-Sevilla JA, Garzón J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. doi: 10.1038/sj.bjp.0703294. PMID: 10781010; PMCID: PMC1572044.

[5] Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, Gasull T, Assumpció Boronat M, Trullas R, Villarroel A, Lerma J, García-Sevilla JA. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. Br J Pharmacol. 1999 Jul;127(6):1317-26. doi: 10.1038/sj.bjp.0702679. PMID: 10455281; PMCID: PMC1760666.

6: Escribá PV, Ozaita A, García-Sevilla JA. Pharmacologic characterization of imidazoline receptor proteins identified by immunologic techniques and other methods. Ann N Y Acad Sci. 1999 Jun 21;881:8-25. doi: 10.1111/j.1749-6632.1999.tb09336.x. PMID: 10415892.7: Boronat MA, Olmos G, García-Sevilla JA. Attenuation of tolerance to opioid- induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands. Br J Pharmacol. 1998 Sep;125(1):175-85. doi: 10.1038/sj.bjp.0702031. PMID: 9776358; PMCID: PMC1565592.8: Ozaita A, Olmos G, Boronat MA, Lizcano JM, Unzeta M, García-Sevilla JA. Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver. Br J Pharmacol. 1997 Jul;121(5):901-12. doi: 10.1038/sj.bjp.0701214. PMID: 9222546; PMCID: PMC1564771.9: Hosseini AR, King PR, Louis WJ, Gundlach AL. [3H]2-(2-Benzofuranyl)-2-imidazoline, a highly selective radioligand for I2-imidazoline receptor binding sites. Studies in rabbit kidney membranes. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):131-8. doi: 10.1007/pl00004911. PMID: 9007853.10: Escribá PV, Alemany R, Sastre M, Olmos G, Ozaita A, García-Sevilla JA. Pharmacological modulation of immunoreactive imidazoline receptor proteins in rat brain: relationship with non-adrenoceptor [3H]-idazoxan binding sites. Br J Pharmacol. 1996 Aug;118(8):2029-36. doi: 10.1111/j.1476-5381.1996.tb15640.x. PMID: 8864539; PMCID: PMC1909863.1

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