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Losulazine HCl

NMR下載 COA and HPLC MSDS下載
names：
InChI=1S/C27H22F4N4O3S.ClH/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;/h1-12,17H,13-16H2,(H,32,33);1H
CAS號(hào)：
81435-67-8
MDL Number：
MF(分子式)： C27H23ClF4N4O3S MW(分子量)： 595
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Losulazine HCl
英文別名	Losulazine hydrochloride; Losulazine HCl; Losulazine monohydrochloride;
CAS號(hào)	81435-67-8
Inchi	(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)(4-((7-(trifluoromethyl)quinolin-4-yl)amino)phenyl)methanone hydrochloride
InchiKey
分子式 Formula	C27H23ClF4N4O3S
分子量 Molecular Weight	595
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Losulazine HCl(CAS:81435-67-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Losulazine HCl is a new antihypertensive agent.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
安全防護(hù)
備注

[1]Pals DT, DeGraaf GL. Cardiovascular effects of losulazine hydrochloride, a peripheral norepinephrine-depleting agent, in nonhuman primates. J Pharmacol Exp Ther. 1985 Feb;232(2):407-12. PubMed PMID: 3968642.

[2]Gore R, Musselman D, Micalizzi E, Slomka M. Losulazine, a new antihypertensive. Clin Pharmacol Ther. 1985 Aug;38(2):195-8. PubMed PMID: 4017421.

[3] Pals DT. Hormonal and cardiovascular effects of losulazine hydrochloride in relation to sodium balance in nonhuman primates. Clin Exp Hypertens A. 1986;8(7):1179-88. PubMed PMID: 3533328.

[4] Pan JT, Hooth MJ, Lookingland KJ, Moore KE, Marks TA. Comparison of the effects of losulazine and reserpine on central aminergic neurons. Toxicol Appl Pharmacol. 1993 Nov;123(1):26-33. PubMed PMID: 8236258.

[5] Mesfin GM, Factor SS, Higgins MJ. Pathologic changes in the accessory sex glands of rats treated with a sympatholytic hypotensive agent (losulazine). Toxicol Pathol. 1989;17(3):516-24. PubMed PMID: 2814227.

6: Mesfin GM, Johnson GA, Higgins MJ, Morris DF. Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride. Toxicol Appl Pharmacol. 1987 Jan;87(1):91-101. PubMed PMID: 3099429.7: Morris DF, Marks TA, Mesfin GM. Effects of losulazine on rat reproduction and development. Fundam Appl Toxicol. 1987 Oct;9(3):573-87. PubMed PMID: 3692015.8: Poppe SM, Marks TA, Mesfin GM, Soule DL, Shaw CI, Morris DF, Black DL. Reproductive and developmental effects on rats after prenatal, postnatal, or pre- and postnatal exposure to the hypotensive agent losulazine. Teratology. 1987 Oct;36(2):171-80. PubMed PMID: 3424203.9: McCall JM, TenBrink RE, Kamdar BV, Skaletzky LL, Perricone SC, Piper RC, Delehanty PJ. 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. J Med Chem. 1986 Jan;29(1):133-7. PubMed PMID: 3941407.10: Ray A, Chatterjee S, Biswas NM. Study on the activities of testes and accessory sex glands after losulazine treatment in rats. Toxicol Lett. 1994 Sep;73(3):175-83. PubMed PMID: 8091426.1

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