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Litoxetine

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names：
4-(naphthalen-2-ylmethoxy)piperidine
CAS號(hào)：
86811-09-8
MDL Number：
MF(分子式)： C16H19NO MW(分子量)： 241.33
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	Litoxetine
英文別名	Litoxetine; Litoxetina; Litoxetinum;
CAS號(hào)	86811-09-8
Inchi	InChI=1S/C16H19NO/c1-2-4-15-11-13(5-6-14(15)3-1)12-18-16-7-9-17-10-8-16/h1-6,11,16-17H,7-10,12H2
InchiKey	MJJDYOLPMGIWND-UHFFFAOYSA-N
分子式 Formula	C16H19NO
分子量 Molecular Weight	241.33
溶解度Solubility
性狀	Solid powder
儲(chǔ)藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產(chǎn)品說明	Litoxetine(CAS:86811-09-8):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。
Introduction	Litoxetine is a serotonin uptake inhibitor.
Application1
Application2
Application3

警示圖
危險(xiǎn)性	Warning
危險(xiǎn)性警示
安全聲明
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[1]Lucchelli A, Santagostino-Barbone MG, Masoero E, Baiardi P, Tonini M. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundam Clin Pharmacol. 1999;13(3):330-6. PubMed PMID: 10392309.

[2]Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I. The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Br J Clin Pharmacol. 1995 Aug;40(2):119-25. PubMed PMID: 8562293; PubMed Central PMCID: PMC1365170.

[3] Patat A, Trocherie S, Thébault JJ, Rosenzweig P, Dubruc C, Bianchetti G, Morselli PL, Court LA. EEG profile of litoxetine after single and repeated administration in healthy volunteers. Br J Clin Pharmacol. 1994 Feb;37(2):157-63. PubMed PMID: 8186061; PubMed Central PMCID: PMC1364592.

[4] Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ. Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45. PubMed PMID: 8385615.

[5] Perrault G, Morel E, Zivkovic B, Sanger DJ. Activity of litoxetine and other serotonin uptake inhibitors in the tail suspension test in mice. Pharmacol Biochem Behav. 1992 May;42(1):45-7. PubMed PMID: 1528946.

6: Lucchelli A, Santagostino-Barbone MG, Barbieri A, Candura SM, Tonini M. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Br J Pharmacol. 1995 Mar;114(5):1017-25. PubMed PMID: 7780635; PubMed Central PMCID: PMC1510312.7: Andrews M, Brown A, Chiva JY, Fradet D, Gordon D, Lansdell M, MacKenny M. Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. doi: 10.1016/j.bmcl.2009.02.054. Epub 2009 Feb 20. PubMed PMID: 19282174.8: Andrews M, Brown A, Chiva JY, Fradet D, Gordon D, Lansdell M, MacKenny M. Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. doi: 10.1016/j.bmcl.2009.08.066. Epub 2009 Aug 21. PubMed PMID: 19740658.9: Graham D, Langer SZ. Advances in sodium-ion coupled biogenic amine transporters. Life Sci. 1992;51(9):631-45. Review. PubMed PMID: 1501510.10: Angel I, Taranger MA, Claustre Y, Scatton B, Langer SZ. Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3H-mazindol binding in vitro. Life Sci. 1988;43(8):651-8. PubMed PMID: 3261828.1

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